Skip to main content

Table 4 Spatial distribution of pfdhfr and pfdhps allele combinations

From: Polymorphism in drug resistance genes dihydrofolate reductase and dihydropteroate synthase in Plasmodium falciparum in some states of India

Genotypes pfdhfr-pfdhps allele combination Resistance levelb Jharkhand (n=84) Odisha (n=70) Andhra Pradesh (n=32) Uttar Pradesh (n=31) Total (n=217)
Wild genotype        
  GEN 1 ANCSI-SAKAA S 3 (3.57) 21 (30.00) 14 (43.75)   38 (17.51)
Mutant genotypes        
  GEN 2 ANCN aI-SAKAA S/RI 4 (4.76) 1 (1.43) 3 (9.38) 4 (12.90) 12 (5.53)
GEN 3 ANR a N aI-SAKAA S/RI 45 (53.57) 28 (41.43) 15 (46.88) 27 (87.10) 115 (52.99)
GEN 4 ANRNI-SGKAA RI 1 (1.19) 1 (1.43)    2 (0.92)
GEN 5 ANR a NI-AAKAA RI   1 (1.43)    1 (0.46)
GEN 6 ANR a N aI-SAE aAA RI   2 (2.86)    2 (0.92)
GEN 7 AI a RNI-SAKAA RI/RII   3 (4.29)    3 (1.38)
GEN 8 ANRNL a-SAKAA RII 4 (4.76) 2 (2.86)    6 (2.76)
GEN 9 ANR a N aI-SG aKG aA RII 18 (21.42)     18(8.29)
GEN 10 ANRNL-SG aKG aA RII 1 (1.19)     1 (0.46)
GEN 11 ANRNI-A a GEAA RII/RIII 4 (4.76) 8 (11.42)    12 (5.52)
GEN 12 ANR a N aI-A a G a E a G aA RIII 1 (1.19)     1 (0.46)
GEN 13 ANR a N a L a-A a G a E aAA RIII 3 (3.57) 3 (4.29)    6 (2.76)
  1. amixed (wild + mutant)
  2. bresistance level classified as per Ahmed et al. [18]