Polymorphism in drug resistance genes dihydrofolate reductase and dihydropteroate synthase in Plasmodium falciparum in some states of India

Table 4 Spatial distribution of pfdhfr and pfdhps allele combinations

Genotypes		pfdhfr-pfdhps allele combination	Resistance level^b	Jharkhand (n=84)	Odisha (n=70)	Andhra Pradesh (n=32)	Uttar Pradesh (n=31)	Total (n=217)
Wild genotype
	GEN 1	ANCSI-SAKAA	S	3 (3.57)	21 (30.00)	14 (43.75)		38 (17.51)
Mutant genotypes
	GEN 2	ANCN ^aI-SAKAA	S/RI	4 (4.76)	1 (1.43)	3 (9.38)	4 (12.90)	12 (5.53)
	GEN 3	ANR ^a N ^aI-SAKAA	S/RI	45 (53.57)	28 (41.43)	15 (46.88)	27 (87.10)	115 (52.99)
	GEN 4	ANRNI-SGKAA	RI	1 (1.19)	1 (1.43)			2 (0.92)
	GEN 5	ANR ^a NI-AAKAA	RI		1 (1.43)			1 (0.46)
	GEN 6	ANR ^a N ^aI-SAE ^aAA	RI		2 (2.86)			2 (0.92)
	GEN 7	AI ^a RNI-SAKAA	RI/RII		3 (4.29)			3 (1.38)
	GEN 8	ANRNL ^a-SAKAA	RII	4 (4.76)	2 (2.86)			6 (2.76)
	GEN 9	ANR ^a N ^aI-SG ^aKG ^aA	RII	18 (21.42)				18(8.29)
	GEN 10	ANRNL-SG ^aKG ^aA	RII	1 (1.19)				1 (0.46)
	GEN 11	ANRNI-A ^a GEAA	RII/RIII	4 (4.76)	8 (11.42)			12 (5.52)
	GEN 12	ANR ^a N ^aI-A ^a G ^a E ^a G ^aA	RIII	1 (1.19)				1 (0.46)
	GEN 13	ANR ^a N ^a L ^a-A ^a G ^a E ^aAA	RIII	3 (3.57)	3 (4.29)			6 (2.76)