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Fig. 1 | Parasites & Vectors

Fig. 1

From: Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis

Fig. 1

Multiple sequence alignment (MSA) of β-CA protein sequences from 10 nematodes. Only the central region of the sequences (85 amino acids, starting 3 amino acids prior to first highly conserved motif) are shown in this alignment. MSA revealed that all of them including AlBCA contain the first (CXDXR; C: cysteine, D: aspartic acid, R: arginine, X: any residue) and second (HXXC; H: histidine, C: cysteine, X: any residue) highly conserved sequences, which have been indicated by two black arrows at the bottom. Zinc ion (Zn2+) is the metal cofactor in catalytic active site of β-CAs, which binds to Cys from the first motif and His and Cys from the second motif [55]

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