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Table 6 Microfilariae counts in snips taken around 1 cm from patch application areas before and after the application of the OCP and LTS-2 DEC patches

From: Diagnosis of O. volvulus infection via skin exposure to diethylcarbamazine: clinical evaluation of a transdermal delivery technology-based patch

  Left iliac crest (OCP-patch site) Right iliac crest (LTS-2 patch site)
  Microfilariae/mg skin Microfilariae/mg skin
Study day Screening Day 4 Day 8 Screening Day 4 Day 8
Days relative to patch application −3 3 7 - 7 −1 3
 Mean ± SDa 7.73 ± 8.09 9.63 ± 9.92 6.63 ± 8.801 6.61 ± 9.49 8.06 ± 9.55 7.44 ± 12.08
 Rangea 0.3 – 31.8 0.0 – 36.9 0.0 – 32.6 0.0 – 47.7 0.0 – 36.9 0.5 – 62.0
 Lowest count eliciting local reaction at 24 hrsa 0.3 0 0.6 0 0 0.5
 Highest count not eliciting local reaction at 30 ha 5.3 12.7 5.6 NA NA NA
Intra-individual difference in skin mf/mg Day 4 – Screening Day 8 - Screening Day 8 – Day 4 Day 4 – Screening Day 8 - Screening Day 8 – Day 4
 Mean differencea 1.90 −1.10 −3.00 1.45 0.83 −0.62
 SD of difference 6.27 5.67 6.12 8.46 10.26 8.58
 Median of difference 0.00 −0.35 −0.30 0.50 0.55 −0.20
 Range of difference −7.6–17.9 −11.8–10.5 −17.4–5.2 −28.3–18.8 −18.0–47.3 −22.1–28.5
  1. aAcross snips from the respective location and time from all 30 participants. Screening = Taken on admission and equivalent to day 0 for OCP-patch. Day 4 = 3 days after application of OCP-patch and day 0 for LTS-2 patch. Day 8 = 3 days after application of LTS-2 patch. SD standard deviation
  2. 1 p = 0.0228 for comparison of Day 4 and Day 8 skin mf level at the left iliac crest, all other comparisons p > 0.2