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Table 6 Microfilariae counts in snips taken around 1 cm from patch application areas before and after the application of the OCP and LTS-2 DEC patches

From: Diagnosis of O. volvulus infection via skin exposure to diethylcarbamazine: clinical evaluation of a transdermal delivery technology-based patch

 

Left iliac crest (OCP-patch site)

Right iliac crest (LTS-2 patch site)

 

Microfilariae/mg skin

Microfilariae/mg skin

Study day

Screening

Day 4

Day 8

Screening

Day 4

Day 8

Days relative to patch application

−3

3

7

- 7

−1

3

 Mean ± SDa

7.73 ± 8.09

9.63 ± 9.92

6.63 ± 8.801

6.61 ± 9.49

8.06 ± 9.55

7.44 ± 12.08

 Rangea

0.3 – 31.8

0.0 – 36.9

0.0 – 32.6

0.0 – 47.7

0.0 – 36.9

0.5 – 62.0

 Lowest count eliciting local reaction at 24 hrsa

0.3

0

0.6

0

0

0.5

 Highest count not eliciting local reaction at 30 ha

5.3

12.7

5.6

NA

NA

NA

Intra-individual difference in skin mf/mg

Day 4 – Screening

Day 8 - Screening

Day 8 – Day 4

Day 4 – Screening

Day 8 - Screening

Day 8 – Day 4

 Mean differencea

1.90

−1.10

−3.00

1.45

0.83

−0.62

 SD of difference

6.27

5.67

6.12

8.46

10.26

8.58

 Median of difference

0.00

−0.35

−0.30

0.50

0.55

−0.20

 Range of difference

−7.6–17.9

−11.8–10.5

−17.4–5.2

−28.3–18.8

−18.0–47.3

−22.1–28.5

  1. aAcross snips from the respective location and time from all 30 participants. Screening = Taken on admission and equivalent to day 0 for OCP-patch. Day 4 = 3 days after application of OCP-patch and day 0 for LTS-2 patch. Day 8 = 3 days after application of LTS-2 patch. SD standard deviation
  2. 1 p = 0.0228 for comparison of Day 4 and Day 8 skin mf level at the left iliac crest, all other comparisons p > 0.2