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Table 7 Proportion of subjects with local reaction by skin mf level measured 1 cm away from patch application area before application and by mean skin mf level across all skin snips taken

From: Diagnosis of O. volvulus infection via skin exposure to diethylcarbamazine: clinical evaluation of a transdermal delivery technology-based patch

OCP-patch LTS-2 patch
Skin 1 cm from patch area pre application % of subjects by score at 24 h % of subjects by score at 30 h Skin 1 cm from patch area pre application % of subjects by score at 24 h % of subjects by score at 30 h
mf/mg N 1 ≥2 1 ≥2 mf/mg N 1 ≥2 1 ≥2
<1.0 5 20.0 40 0 100 <1.0 7 28.6 57.1 0 100
1–5 10 40.0 60 0 90.0 1–5 9 0 77.8 0 100
>5 15 13.3 80 0 93.3 >5 14 14.3 71.4 0 100
All snips    All snips   
mf/mg N 1 ≥2 1 ≥2 mf/mg N 1 ≥2 1 ≥2
<1.0 5 40.0 40.0 0 100 <1.0 5 20 80 0 100
1–5 8 37.5 50.0 0 100 1–5 8 12.5 71.4 0 100
>5 17 11.8 82.4 0 88.3 >5 17 11.8 70.6 0 100
Any 30 23.3 66.7 0 93.3 Any 30 13.3 70.0 0 100
   ≥1 ≥1    ≥1 ≥1
Any 30 90 93.3 Any 30 83.3 100