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Table 2 Ivermectin pharmacokinetic parameters in dogs following oral administration (0.3 mg/kg BW) alone or concurrently with fluralaner (56 mg/kg BW)

From: Plasma pharmacokinetic profile of fluralaner (Bravecto™) and ivermectin following concurrent administration to dogs

Parameter

Unit

Ivermectin

Ivermectin plus Fluralaner

P-value

Mean ± SD

Mean ± SD

Cmax

(ng/mL)

92.70 ± 26.77

80.52 ± 21.41

0.2465

tmax

(day)

0.29 ± 0.10

0.31 ± 0.11

0.7269

AUC∞

(day*ng/mL)

141.96 ± 27.23

134.26 ± 37.99

0.5073

t½

(days)

2.07 ± 0.71

1.84 ± 0.42

0.4888

  1. SD standard deviation
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Parasites & Vectors

ISSN: 1756-3305

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