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Table 3 Fluralaner pharmacokinetic parameters in dogs following oral administration (56 mg/kg BW) alone or concurrently with ivermectin (0.3 mg/kg BW)

From: Plasma pharmacokinetic profile of fluralaner (Bravecto™) and ivermectin following concurrent administration to dogs

Parameter Unit Fluralaner Fluralaner plus Ivermectin P-value
Mean ± SD Mean ± SD
Cmax (ng/mL) 7976 ± 4239 9312 ± 1767 0.1529
tmax (day) 3.00 ± 1.49 3.20 ± 2.66 0.8379
AUC (day*ng/mL) 175778 ± 75122 184030 ± 49524 0.5373
(days) 14.27 ± 2.53 13.45 ± 1.68 0.5107
  1. SD standard deviation