Table 3 Fluralaner pharmacokinetic parameters in dogs following oral administration (56 mg/kg BW) alone or concurrently with ivermectin (0.3 mg/kg BW)
Parameter | Unit | Fluralaner | Fluralaner plus Ivermectin | P-value |
|---|---|---|---|---|
Mean ± SD | Mean ± SD | |||
Cmax | (ng/mL) | 7976 ± 4239 | 9312 ± 1767 | 0.1529 |
tmax | (day) | 3.00 ± 1.49 | 3.20 ± 2.66 | 0.8379 |
AUC∞ | (day*ng/mL) | 175778 ± 75122 | 184030 ± 49524 | 0.5373 |
t½ | (days) | 14.27 ± 2.53 | 13.45 ± 1.68 | 0.5107 |