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Table 2 Parameter assumptions used for the comparisons presented in this paper

From: Required duration of mass ivermectin treatment for onchocerciasis elimination in Africa: a comparative modelling analysis

Assumption ONCHOSIM EPIONCHO
Life expectancy of adult worms 10 years [38] 10 years [38]
Life expectancy of microfilariae 0.75 years [58] 1.25 years [59]
Distribution of worm survival times Weibull Exponential
Proportion of blood meals taken by vectors on humans 0.96 [30] and expert opinion 0.96 (matched to ONCHOSIM)a
Macrofilaricidal effect of ivermectin Not included Not included
Microfilaricidal effect of ivermectin 100 %, instantaneous upon administration [36] 98-99 % at 2 mo. post-treatment following [40]
Embryostatic effect of ivermectin All female worms temporarily stop producing mf but resume production gradually, reaching maximum production capacity 11 months post-treatment on average [36] Fertile worms exposed to ivermectin decrease their mf production according to the dynamics presented in [40] and would fully recover if further untreated
Cumulative effect on mf production by adult worms 35 % reduction in the rate of mf production per dose, on average [36]. 35 % reduction in the rate of mf production per dose [36]a
  1. aDifferent values were applied in previous publications, but for the current model comparison presented in this paper the assumptions were harmonized with those in ONCHOSIM