|
Life expectancy of adult worms
|
10 years [38]
|
10 years [38]
|
|
Life expectancy of microfilariae
|
0.75 years [58]
|
1.25 years [59]
|
|
Distribution of worm survival times
|
Weibull
|
Exponential
|
|
Proportion of blood meals taken by vectors on humans
|
0.96 [30] and expert opinion
|
0.96 (matched to ONCHOSIM)a
|
|
Macrofilaricidal effect of ivermectin
|
Not included
|
Not included
|
|
Microfilaricidal effect of ivermectin
|
100 %, instantaneous upon administration [36]
|
98-99 % at 2 mo. post-treatment following [40]
|
|
Embryostatic effect of ivermectin
|
All female worms temporarily stop producing mf but resume production gradually, reaching maximum production capacity 11 months post-treatment on average [36]
|
Fertile worms exposed to ivermectin decrease their mf production according to the dynamics presented in [40] and would fully recover if further untreated
|
|
Cumulative effect on mf production by adult worms
|
35 % reduction in the rate of mf production per dose, on average [36].
|
35 % reduction in the rate of mf production per dose [36]a
|
