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Table 2 ELISA titers in mice immunized with rVtp5, rVtp6 or only adjuvant when tested with Borrelia hermsii whole-cell lysates DAH or LAK-3

From: Vaccination with the variable tick protein of the relapsing fever spirochete Borrelia hermsii protects mice from infection by tick-bite

Tested with DAH whole-cell lysate

Vaccine

Number of Mice

Titers*

Adjuvant only

(N = 5)

all <1:200

Vtp6 (DAH)

(N = 5)

all ≥ 1:512,000

Vtp5 (LAK-3)

(N = 5)

1:200; 3 @ 1:5.400; ≥ 1:16,200

Tested to LAK-3 whole-cell lysate

Vaccine

Number of Mice

Titers**

Adjuvant only

(N = 5)

2 @ < 1:200; 1:200; 1:400; 1:800

Vtp6 (DAH)

(N = 5)

1:16,000; 2 @ 1:64,000; 2 @ 1:128,000

Vtp5 (LAK-3)

(N = 5)

all ≥ 1:512,000

  1. Geometric mean titers of each group significantly different, *p = 0.0008; **p = 0.0001