Speed of flea knockdown of spinosad compared to afoxolaner, and of spinosad through 28 days post-treatment in controlled laboratory studies

Table 6 Study 2: mean (standard error) (SE) live flea counts^a of control, afoxolaner and spinosad group dogs

	Mean	Control	Afoxolaner	Spinosad
Day 0 - 1 hour	Geometric	81.2 (0.1)	86.0 (0.1)	71.0 (0.1)
	Arithmetic	81.8 (4.2)	86.3 (4.2)	71.8 (4.2)^b
Day 0 - 3 hours	Geometric	89.8 (0.3)	33.9 (0.3)^c	0.0 (0.0)^d,e
	Arithmetic	90.0 (9.6)	51.2 (9.6)^c	0.0 (0.0)^d,e
Day 7 - 1 hour	Geometric	89.9 (0.4)	88.9 (0.4)	4.0 (0.4)^d,e
	Arithmetic	90.3 (3.9)	89.2 (3.9)	9.5 (3.9)^d,e
Day 7 - 3 hours	Geometric	89.8 (0.1)	54.3 (0.1)^f	0.0 (0.6)^d,e
	Arithmetic	89.8 (0.1)	56.7 (4.1)^f	0.0 (0.0)^d,e

^aCounts of live fleas with normal movement; excludes those with abnormal movement, classified as moribund
Treated group different from control: ^c p ≤ 0.0220; ^d p < 0.0001; ^f p ≤ 0.0006
Different from afoxolaner: ^b p = 0.0276; ^e p < 0.0001

ISSN: 1756-3305