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Table 1 Scoring categories used to rank Haemonchus contortus kinases and prioritise them as potential drug targets

From: The Haemonchus contortus kinome - a resource for fundamental molecular investigations and drug discovery

Scoring category

Score

Transcribed in parasitic stage (L4 and/or adults)

required

Lethal phenotype in Caenorhabditis elegans homolog upon RNAi

1

Associated with a unique function in a pathway (“chokepoint”)

1

Unique classification (group/family/subfamily)

1

> 80 % sequence similarity and > 50 % coverage to C. elegans homolog

1

≤ 41.45 % sequence similarity to closest homolog in sheep

1

> 80 % sequence similarity and > 50 % coverage to D. filaria and/or Te. circumcincta

0.5–1

Associated compound in Kinase SARfari

1

Associated compound in DrugBank

1

> 5 associated compound in Kinase SARfari

1

> 5 associated compound in DrugBank

1

  1. Transcription in at least one parasitic stage was required for a kinase to be considered as a target. Similarity to kinase sequences of one or two related strongylid nematodes (Dictyocaulus filaria and/or Teladorsa gia circumcincta) of sheep was rewarded with half a point per species. All other categories were given one point
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Parasites & Vectors

ISSN: 1756-3305

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