Genetic diversity of transmission-blocking vaccine candidate Pvs48/45 in Plasmodium vivax populations in China

Parasites & Vectors

Table 1 Nucleotide variations and summary statistics of Pvs48/45 in 200 P. vivax isolates from China

Population	n	S	π	Tajima’s D	d_N-d_S	MK (P. cynomolgi)	MK (P. knowlesi)
Pvs48/45 (31–1332 bp)
China	200	12	0.0012	−0.48702	2.028*	0.0026**	0.0126*
Yunan-2004	39	4	0.0007	−0.9270	1.676*	0.0097**	0.0247*
Yunan-2008-10	100	11	0.0012	−0.62065	1.665*	0.0065**	0.0534
Anhui-2008-10	61	6	0.0010	0.06240	2.166*	0.0009***	0.0039**
Domain I (142–483 bp)
China	200	0	-	-	-	-
Domain II (892–1254 bp)
China	200	6	0.002	−0.4784	1.764*	0.0199*	NS
Yunan-2004	39	2	0.0004	−1.2936	1.380	NS	NS
Yunan-2008-10	100	5	0.0025	−0.3126	1.565	NS	NS
Anhui-2008-10	61	4	0.0021	−0.2088	1.996*	0.0131*	0.0268*
Inter-domain region (484–891 bp)
China	200	4	0.0008	−0.9357	0.575	NS	NS
Yunan-2004	39	1	0.0011	1.3354	0.996	NS	NS
Yunan-2008-10	100	4	0.0004	−0.8926	−0.888	NS	NS
Anhui-2008-10	61	1	0.0002	−1.5282	0.992	NS	NS

n no. of isolates, S no. of SNPs, TD, MK mcdonald-kreitman test, * P < 0.05, **, P < 0.01, ***, P < 0.001, NS non-significant

ISSN: 1756-3305