Areas
|
Mutations
|
Amino acid and genetic changesb
|
Number of isolates (%)c
|
---|
2006–2007 (n = 95)
|
2013–2014 (n = 85)
|
---|
Mitsoudje Center Hospital
|
Synonymous
|
R471R (CGT → CGC)
|
0 (0)
|
1 (1.2)
|
G538G (GGT → GGA)
|
1 (1.1)
|
2 (2.4)
|
Non-synonymous
|
D464H (GAT → CAT)
|
0 (0)
|
1 (1.2)
|
D464Y (GAT → TAT)
|
0 (0)
|
1 (1.2)
|
L488S (TTG → TCG)
|
0 (0)
|
1 (1.2)
|
I526M (ATA → ATG)
|
0 (0)
|
1 (1.2)
|
A578S (GCT → TCT)
|
0 (0)
|
2 (2.4)
|
D584E (GAT → GAA)
|
1 (1.1)
|
1 (1.2)
|
National Malaria Center
|
Synonymous
|
Y500Y (TAT → TAC)
|
0 (0)
|
1 (1.2)
|
Non-synonymous
|
D464H (GAT → CAT)
|
0 (0)
|
1 (1.2)
|
S477Y (TCT → TAT)
|
0 (0)
|
1 (1.2)
|
I526M (ATA → ATG)
|
0 (0)
|
1 (1.2)
|
A578S (GCT → TCT)
|
0 (0)
|
2 (2.4)
|
Mitsamiouli Center Hospital
|
Synonymous
|
Y500Y (TAT → TAC)
|
0 (0)
|
1 (1.2)
|
Non-synonymous
|
D464Y (GAT → TAT)
|
0 (0)
|
2 (2.4)
|
S477Y (TCT → TAT)
|
1 (1.1)
|
1 (1.2)
|
A504T (GCT → ACT)
|
0 (0)
|
1 (1.2)
|
D584E (GAT → GAA)
|
0 (0)
|
2 (2.4)
|
-
aIsolates collected from 2006 to 2007 and 2013 to 2014 along Grande Comore Island of Comoros
-
bThe mutated amino acids and nucleotides are indicated in bold type
-
cStatistically significant differences for comparison with isolates circulating in 2006–2007 from Grande Comore Island (*P < 0.05) using Mann–Whitney U test