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Table 2 Prevalence of K13-propeller mutations in Plasmodium falciparum isolatesa

From: Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy

Areas Mutations Amino acid and genetic changesb Number of isolates (%)c
2006–2007 (n = 95) 2013–2014 (n = 85)
Mitsoudje Center Hospital Synonymous R471R (CGT → CGC) 0 (0) 1 (1.2)
G538G (GGT → GGA) 1 (1.1) 2 (2.4)
Non-synonymous D464H (GAT → CAT) 0 (0) 1 (1.2)
D464Y (GAT → TAT) 0 (0) 1 (1.2)
L488S (TTG → TCG) 0 (0) 1 (1.2)
I526M (ATA → ATG) 0 (0) 1 (1.2)
A578S (GCT → TCT) 0 (0) 2 (2.4)
D584E (GAT → GAA) 1 (1.1) 1 (1.2)
National Malaria Center Synonymous Y500Y (TAT → TAC) 0 (0) 1 (1.2)
Non-synonymous D464H (GAT → CAT) 0 (0) 1 (1.2)
S477Y (TCT → TAT) 0 (0) 1 (1.2)
I526M (ATA → ATG) 0 (0) 1 (1.2)
A578S (GCT → TCT) 0 (0) 2 (2.4)
Mitsamiouli Center Hospital Synonymous Y500Y (TAT → TAC) 0 (0) 1 (1.2)
Non-synonymous D464Y (GAT → TAT) 0 (0) 2 (2.4)
S477Y (TCT → TAT) 1 (1.1) 1 (1.2)
A504T (GCT → ACT) 0 (0) 1 (1.2)
D584E (GAT → GAA) 0 (0) 2 (2.4)
  1. aIsolates collected from 2006 to 2007 and 2013 to 2014 along Grande Comore Island of Comoros
  2. bThe mutated amino acids and nucleotides are indicated in bold type
  3. cStatistically significant differences for comparison with isolates circulating in 2006–2007 from Grande Comore Island (*P < 0.05) using Mann–Whitney U test
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Parasites & Vectors

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