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Table 3 Prevalence of single nucleotide polymorphisms and multi-mutated haplotypes in Plasmodium falciparum K13-propeller genea

From: Polymorphisms of the artemisinin resistant marker (K13) in Plasmodium falciparum parasite populations of Grande Comore Island 10 years after artemisinin combination therapy

Areas

Genotypes

Number of isolates (%)b

2006–2007 (n = 95)

2013–2014 (n = 85)

Mitsoudje Center Hospital

Wild-type haplotype D464S477L488A504I526A578D584

30 (31.6)

20 (23.5)*

Single-mutant haplotype H 464S477L488A504I526A578D584

0 (0)

1 (1.2)

Single-mutant haplotype Y 464S477L488A504I526A578D584

0 (0)

1 (1.2)

Single-mutant haplotype D464S477 S 488A504I526A578D584

0 (0)

1 (1.2)

Single-mutant haplotype D464S477L488A504I526 S 578D584

0 (0)

1 (1.2)

Single-mutant haplotype D464S477L488A504I526A578 E 584

1 (1.1)

1 (1.2)

Double-mutant haplotype D464S477L488A504 M 526 S 578D584

0 (0)

1 (1.2)

National Malaria Center

Wild-type haplotype D464S477L488A504I526A578D584

45 (47.4)

33 (38.9)*

Single-mutant haplotype H 464S477L488A504I526A578D584

0 (0)

1 (1.2)

Single-mutant haplotype D464 Y 477L488A504I526A578D584

0 (0)

1 (1.2)

Single-mutant haplotype D464S477L488A504 M 526A578D584

0 (0)

1 (1.2)

Single-mutant haplotype D464S477L488A504I526 S 578D584

0 (0)

2 (2.4)

Mitsamiouli Center Hospital

Wild-type haplotype D464S477L488A504I526A578D584

18 (18.9)

16 (18.8)

Single-mutant haplotype Y 464S477L488A504I526A578D584

0 (0)

2 (2.4)

Single-mutant haplotype D464 Y 477L488A504I526A578D584

1 (1.1)

0 (0)

Single-mutant haplotype D464S477L488A504I526A578 E 584

0 (0)

2 (2.4)

Double-mutant haplotype D464 Y 477L488 T 504I526A578D584

0 (0)

1 (1.2)

  1. Note: The double mutants were confirmed in repeated amplification and sequencing experiments
  2. aIn isolates collected from 2006 to 2007 and 2013 to 2014 along Grande Comore Island, Union of Comoros. The mutated amino acids are indicated by bold type
  3. bStatistically significant differences for comparison with isolates circulating in 2006–2007 from Grande Comore Island (*P < 0.05) using Mann–Whitney U test
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Parasites & Vectors

ISSN: 1756-3305

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