Protection of dogs against canine heartworm infection 28 days after four monthly treatments with Advantage Multi® for Dogs

Table 1 Worm recoveries from dogs treated with 4 monthly doses of Advantage Multi for Dogs with the last treatment being 28 days before being inoculated with L3 Dirofilaria immitis larvae from mosquitoes. Shown in the table are the dogs’ IDs and gender, ELISA OD value on Day 264 (152 days after inoculation with larvae), and the number of male, female, and total worms recovered from each dog

			Number of Worms Recovered
Dog ID	Gender	ELISA OD Day 264	Males	Females	Total
DOGS TREATED WITH ADVANTAGE MULTI® FOR DOGS
501	Male	0.055	0	0	0
701	Male	0.052	0	0	0
801	Male	0.054	0	0	0
601	Male	0.057	0	0	0
505	Female	0.060	0	0	0
705	Female	0.056	0	0	0
703	Female	0.054	0	0	0
704	Female	0.056	0	0	0
Geometric mean:			0.00	0.00	0.00
NONTREATED CONTROL DOGS
502	Male	0.063	12	22	34
702	Male	0.055	7	18	25
306	Male	0.080*	13	21	34
401	Male	0.055	14	17	31
504	Female	0.093*	13	24	37
506	Female	0.090*	20	21	41
503	Female	0.079*	13	23	36
602	Female	0.090*	21	15	36
Geometric mean:			13.47	19.90	33.94

*The asterisk next to the OD (Optical Density) indicates these dogs were considered antigen positive because the OD reading was >0.005 above the negative control reading of 0.067

ISSN: 1756-3305