Table 3 Treatment effects of oxadiazole-2-oxides on adult S. japonicum in mice
Groups | Mice No. | Number of worms (Mean ± SD) | Worm reduction rate (%) | Number of eggs per gram of liver (Mean ± SD) | Egg reduction rate (%) |
|---|---|---|---|---|---|
Control | 7 | 12.0 ± 2.1 |  | 8032.9 ± 2192.1 |  |
Compound 4a | 4 | 4.0 ± 2.5 (P > 0.05**) | 66.7 (P < 0.01*) | 7730.8 ± 1457.8 (P < 0.05**) | 3.8 (P > 0.05*) |
Compound 4b | 4 | 9.0 ± 3.8 (P < 0.05**) | 25.0 (P > 0.05*) | 7007.8 ± 2420.2 (P < 0.05**) | 12.8 (P > 0.05*) |
Compound 7c | 6 | 12.0 ± 3.9 (P < 0.05**) | – | 7213.0 ± 2658.0 (P < 0.05**) | 10.2 (P > 0.05*) |
Compound 13 | 5 | 8.6 ± 2.4 (P < 0.05**) | 28.3 (P < 0.05*) | 8201.4 ± 2066.0 (P < 0.05**) | – |
Compound 16 | 5 | 3.7 ± 1.4 (P > 0.05**) | 69.4 (P < 0.01*) | 6424.1 ± 1193.4 (P < 0.05**) | 20.0 (P > 0.05*) |
Compound 20 | 6 | 4.7 ± 1.1 (P > 0.05**) | 61.1 (P < 0.01*) | 10094.7 ± 1691.0 (P < 0.05**) | – |
PZQ | 6 | 3.3 ± 1.7 | 72.3 (P < 0.01*) | 3721.5 ± 1600.6 | 53.7 (P < 0.01*) |