Table 1 Mean live Ixodes scapularis counts and efficacy relative to placebo at 8 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0

Placebo

Range

20–40

12–32

17–37

18–40

12–32

15–34

A. mean

30.3

25.5

25.4

28.6

24.1

23.8

G. mean¹

29.4^a

24.2^a

24.5^a

27.8^a

23.2^a

23.0^a

Sarolaner

Range

15–25

11–24

10–30

13–36

16–35

13–36

A. mean

20.8

16.8

16.1

19.6

25.6

23.1

Efficacy (%)

31.4

34.3

36.5

31.4

0.0

2.6

G. mean¹

20.5^b

16.2^b

15.2^b

18.5^b

25.0^a

21.9^a

Efficacy (%)

30.3

32.8

38.0

33.5

0.0

5.0

P-value vs. placebo

0.0082

0.0174

0.0070

0.0065

0.5822

0.6940

Afoxolaner

Range

12–27

12–27

11–26

17–36

15–34

17–25

A. mean

18.4

21.8

17.6

23.3

23.6

20.0

Efficacy (%)

39.3

14.7

30.5

18.8

2.1

15.8

G. mean¹

17.8^b

21.1^a,b

17.0^b

22.7^a,b

22.7^a

19.9^a

Efficacy (%)

39.6

12.5

30.8

18.5

1.9

13.8

P-value vs. placebo

0.0006

0.3909

0.0309

0.1445

0.8889

0.2619

P-value vs. sarolaner

0.2569

0.1028

0.5023

0.1487

0.4914

0.4585