Table 2 Mean live Ixodes scapularis counts and efficacy relative to placebo at 12 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0

Placebo

Range

20–43

13–30

10–39

15–36

15–36

18–33

A. mean

32.9

23.1

24.4

26.3

23.9

25.4

G. mean¹

32.0^a

22.3^a

22.6^a

25.4^a

23.1^a

24.7^a

Sarolaner

Range

4–22

6–14

0–18

1–26

12–35

1–29

A. mean

9.1

9.5

12.1

10.3

18.6

15.4

Efficacy (%)

72.2

58.9

50.3

61.0

22.0

39.4

G. mean¹

8.0^b

9.1^b

9.5^b

7.9^b

17.5^a

11.6^b

Efficacy (%)

74.9

59.2

58.0

68.8

24.0

53.3

P-value vs. placebo

<0.0001

<0.0001

0.0120

0.0002

0.1054

0.0131

Afoxolaner

Range

5–15

11–29

12–21

12–40

11–38

14–23

A. mean

10.6

18.5

15.9

23.6

21.5

19.3

Efficacy (%)

67.7

20.0

34.9

10.0

9.9

24.1

G. mean¹

10.2^b

17.6^a

15.6^a,b

22.3^a

20.1^a,b

19.0^a,b

Efficacy (%)

68.1

21.2

31.1

12.0

13.0

23.3

P-value vs. placebo

<0.0001

0.1335

0.2460

0.6168

0.4013

0.3512

P-value vs. sarolaner

0.3063

0.0004

0.1369

0.0006

0.4123

0.0949