Table 3 Mean live Ixodes scapularis counts and efficacy relative to placebo at 24 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0

Placebo

Range

26–39

3–32

12–32

4–36

16–32

14–29

A. mean

32.4

23.9

23.4

27.5

23.5

22.9

G. mean¹

32.0^a

20.5^a

22.4^a

23.9^a

23.1^a

22.4^a

Sarolaner

Range

0–1

0–1

0–0

0–3

0–5

0–17

A. mean

0.1

0.3

0.0

0.5

1.3

2.6

Efficacy (%)

99.6

99.0

100

98.2

94.7

88.5

G. mean¹

0.1^b

0.2^b

0.0^c

0.3^c

0.8^c

1.0^c

Efficacy (%)

99.7

99.1

100

98.8

96.6

95.7

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

Afoxolaner

Range

0–2

0–6

0–9

1–15

1–21

0–25

A. mean

0.3

1.8

2.4

6.9

9.0

12.1

Efficacy (%)

99.2

92.7

89.8

75.0

61.7

47.0

G. mean¹

0.1^b

1.0^b

1.1^b

5.3^b

6.5^b

6.8^b

Efficacy (%)

99.5

95.1

95.1

77.9

71.8

69.6

P-value vs. placebo

<0.0001

<0.0001

<0.0001

0.0003

0.0009

0.0310

P-value vs. sarolaner

0.7558

0.1197

0.0278

<0.0001

0.0001

0.0083