New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel

Table 2 Summary of data included in the analysis

Country	Participants	Mean age (SD)	QD protocol^a	PZQ regimen	Follow-up days	Ref.
Schistosoma haematobium
Côte d’Ivoire	6	5 (0)	1 UF × 1 urine sample	1 × 40 mg/kg	21	[20]
Côte d’Ivoire	86	11.1 (1.9)	1 UF × 2 urine samples	1 × 40 mg/kg	21	[21]
Kenya	79	11.3 (3.1)	1 UF × 4 urine samples	1 × 40 mg/kg	42	[19]
Schistosoma mansoni
Côte d’Ivoire	35	3.8 (1.2)	2 KK × 2 stool samples	1 × 40 mg/kg	21	[20]
Uganda	503	4.2 (1.8)	2 KK × 2 stool samples	1 × 40 mg/kg	21	[26]
Côte d’Ivoire	58	11.2 (4.1)	1 KK × 3 stool samples	1 × 40 mg/kg	42	[24]
Côte d’Ivoire	49	8.9 (2.4)	2 KK × 2 stool samples	1 × 40 mg/kg	21	[25]
Côte d’Ivoire	85	10.0 (1.42)	1 KK x 4 stool samples	1 × 40 mg/kg	28	[23]
Côte d’Ivoire	261	9.6 (2.1)	1 KK x 5 stool samples	1 × 60 mg/kg^b	28	[22]

Abbreviations: KK Kato-Katz, PZQ praziquantel, QD quantitative diagnostic, SD standard deviation, UF urine filtration
^aMultiple samples of urine or stool were taken on consecutive days; ^b 2 × 30 mg/kg given 3 hours apart

ISSN: 1756-3305