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Table 6 The effect of covariates on the percentage of egg reduction rates greater than 90 % among children infected with schistosomes following treatment with praziquantel

From: New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel

Covariates Levels Percentage ERR > 90 % (95 % BCI)
Schistosoma haematobium dataset
(Baseline) Côte d’Ivoire; male; younger SAC; 40 mg/kg; 21 days follow-up 95.9 % (89.3 %, 99.1 %)
Country Kenyaa 98.3 % (94.3 %, 99.7 %)
Sex Female 97.3 % (92.2 %, 99.4 %)
Age group Older SAC 92.3 % (82.6 %, 97.6 %)
Schistosoma mansoni dataset
(Baseline) Côte d’Ivoire; male; younger SAC; 40 mg/kg; 21 days follow-up 94.4 % (85.3 %, 98.3 %)
Country Uganda 75.9 % (59.7 %, 86.4 %)
Dose 60 mg/kg 92.3 % (77.8 %, 98.1 %)
Sex Female 92.6 % (81.8 %, 97.6 %)
Age group Pre-SAC 90.9 % (78.1 %, 97.2 %)
  Older SAC 95.5 % (85.8 %, 99.0 %)
Follow-up time 28 days 89.5 % (80.4 %, 95.0 %)
  42 days 59.1 % (39.7 %, 76.4 %)
  1. aChildren in Kenya were followed up for 42 days
  2. Abbreviations: BCI Bayesian credible interval, SAC school-age children