Fig. 6
From: Mechanisms of sex determination and transmission ratio distortion in Aedes aegypti
Female-specific lethality and sex determination. a Punnett square showing tra-2 RNAi segregation in a cross between a heterozygous male and a wild-type female. The knockdown effect driven by the minimal CMV promoter was not enough to cause an obvious effect on sperm activity but specific lethality in mm zygotes was still evident. b Punnett square showing tra-2 RNAi segregation in a homozygous line, resulting in dysfunctional m-chromosome-bearing sperm during spermatogenesis and no surviving female progeny after fertilization. c Hypothetical model of sex determination in Aedesa egypti in which paternal tra-2 mRNA (tra-2pat) is necessary for the activity of m-chromosome-bearing sperms