Fig. 1
From: Reconstruction of the insulin-like signalling pathway of Haemonchus contortus
Heat-map displaying transcription profiles for genes (cf. Table 1) involved in insulin/insulin-like growth factor 1 (IGF1)-like signalling (IIS) in Haemonchus contortus. Hc-ins-1a/1b, −ins-17 and -ins-18 are genes that act upstream (U) of the IIS pathway. Genes Hc-daf-2, −ist-1, −aap-1, −age-1a/1b, −daf-18, −pdk-1, −sgk-1a/1b, −akt-1a/1b, −pptr-1a/1b/1c, −pptr-2, −ftt-2, −par-5 and Hc-daf-16 are part of the core (C) IIS pathway and genes Hc-skn-1, −hsf-1a/1b, −hsb-1, −ddl-1 and Hc-egl-9a/b/c/d are activated downstream (D) of the IIS pathway. Transcription levels in different developmental stages (egg, L1, L2, L3, L4 and A = adult; f = female; m = male) of H. contortus (see colour scale): low (red), medium (orange), high (yellow) and very high (white)