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Table 1 Distribution of the IC50 of pyronaridine and chloroquine and the K76T mutation according to the three components defined by the Bayesian mixture modeling approach

From: The Plasmodium falciparum chloroquine resistance transporter is associated with the ex vivo P. falciparum African parasite response to pyronaridine

  Component A Component B Component C P-value
No of isolates 177 89 30  
Pyronaridine median IC50 15.9 nM 34.2 nM 63.3 nM <0.001
Pyronaridine 25 % percentile 11.2 nM 30.4 nM 51.2 nM  
Pyronaridine 75 % percentile 18.5 nM 37.1 nM 69.7 nM  
Chloroquine median IC50 57.0 nM 90.6 nM 240.5 nM 0.003
Chloroquine 25 % percentile 18.3 nM 19.7 nM 71.2 nM  
Chloroquine 75 % percentile 207 nM 273 nM 301 nM  
No of K76T mutation (%) 82 (46.3) 42 (47.2) 22 (73.3) 0.021