Fig 1
Balance sheet showing the profile of schistosome migration through all organs of the mouse. The numbers of schistosomula detected by compressed organ autoradiography after exposure of mice to 75Se-Methionine-labelled cercariae (reproduced with permission from [22]). Open circles and solid lines are normal mice, closed circles and dashed lines are mice vaccinated five weeks previously with 500 RA cercariae. a and c The vast majority of schistosomula leave the skin and travel to the lungs. d and e The impact of vaccination is revealed by the reduced parasite numbers detected in the systemic organs and accumulating in the portal system, compared to normal mice. b The decline in parasite numbers only begins from day 15 at which time < 10% remain in the skin. The lungs are the principal obstacle to maturation in normal mice, and more so in vaccinated animals