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Table 2 dN/dS measurements for genes encoding vaccine candidates

From: Do schistosome vaccine trials in mice have an intrinsic flaw that generates spurious protection data?

Vaccine candidate

Sma × Sha

Sma × Sja

Sm29

0.83

0.41

TSP-2

0.34 (0.65a)

0.12 (0.33a)

GST-28

0.32

0.16

SmTOR

0.3

0.2

Sjserpin

0.29

0.41

SjTGR

0.29

0.09

SjVLDL

0.27

0.11

Sm22.6

0.21

0.25

StoLP-2

0.2

0.05

Calpain

0.18

0.15

Sm21.7

0.18

0.53

SjCathepsin

0.15

0.13

GAPDH

0.14

0.06

SmRho

0.11

0.13

TPI

0.11

0.13

Sm14

0.11

0.06

Sm23

0.08

0.1

SOD

0.07

0.14

Aldolase

0.05

0.02

Sj22.7

0.04

0.004

Sm14-3-3

0.03

0.19

Myosin heavy chain

0.02

0.03

Paramyosin

0.01

0.04

  1. Sma, Schistosoma mansoni; Sha, S. haematobium; Sja, S. japonicum
  2. aValue for the portion of the gene encoding the exposed
  3. hydrophilic loop utilised in vaccine trials