Table 1 Mean live flea counts and efficacy relative to placebo at 8 h after treatment and post treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0

Placebo

Range

44–99

51–91

69–89

55–92

62–97

75–100

A. mean

69.9

74.9

77.0

79.8

79.1

87.5

G. mean¹

68.1^a

73.3^a

76.6^a

78.8^a

78.4^a

87.1^a

Sarolaner

Range

0–0

0–3

0–0

0–0

0–8

0–5

A. mean

0.0

0.4

0.0

0.0

1.6

0.6

Efficacy (%)

100

99.5

100

100

97.9

99.3

G. mean¹

0.0^c

0.2^c

0.0^c

0.0^c

1.0^c

0.3^c

Efficacy (%)

100

99.7

100

100

98.8

99.7

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

Afoxolaner

Range

0–2

0–35

0–31

0–44

3–66

0–71

A. mean

0.6

6.1

10.1

15.3

27.5

25.0

Efficacy (%)

99.1

91.8

86.9

80.9

65.2

71.4

G. mean¹

0.4^b

2.4 ^b

6.8^b

8.5^b

18.6^b

11.3^b

Efficacy (%)

99.4

96.7

91.1

89.2

76.3

87.0

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

0.0005

0.0005

P-value vs. sarolaner

0.0499

0.0094

<0.0001

<0.0001

<0.0001

<0.0001