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Table 2 Mean live flea counts and efficacy relative to placebo at 12 h after treatment and post treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0

From: Comparative speed of kill of sarolaner (Simparica) and afoxolaner (NexGard®) against induced infestations of Ctenocephalides felis on dogs

Treatment

 

Day of treatment or re-infestation

 

0

7

14

21

28

35

Placebo

Range

40–95

33–79

60–89

48–88

56–85

62–95

A. mean

62.3

59.5

74.6

75.8

70.0

80.4

G. mean1

60.4a

57.0a

74.1a

74.7a

69.3a

79.8a

Sarolaner

Range

0–0

0–2

0–0

0–0

0–0

0–0

A. mean

0.0

0.3

0.0

0.0

0.0

0.0

Efficacy (%)

100

99.6

100

100

100

100

G. mean1

0.0b

0.1b

0.0b

0.0b

0.0c

0.0c

Efficacy (%)

100

99.7

100

100

100

100

P-value vs.placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

Afoxolaner

Range

0–0

0–2

0–2

0–4

0–28

0–25

A. mean

0.0

0.3

0.3

0.9

5.5

4.3

Efficacy (%)

100

99.6

99.7

98.8

92.1

94.7

G. mean1

0.0b

0.1b

0.1b

0.5b

2.5b

1.4b

Efficacy (%)

100

99.7

99.8

99.4

96.4

98.2

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

P-value vs. sarolaner

1.000

1.000

0.2455

0.0713

0.0008

0.0161

  1. 1Geometric means within columns with the same superscript are not significantly different (P > 0.05)