Comparative speed of kill of sarolaner (Simparica™) and fluralaner (Bravecto®) against induced infestations of Ctenocephalides felis on dogs

Table 2 Mean live flea counts and efficacy relative to placebo at 12 hours after initial treatment and post-treatment re-infestations for dogs treated with three monthly oral doses of sarolaner or a single oral dose of fluralaner

Treatment		Day of treatment or re-infestation¹
Treatment		0	14	29	44	59	74	90
Placebo	Range	39–90	54–74	30–91	45–87	37–81	45–82	21–71
	A. mean	68.0	65.3	63.8	65.6	66.9	64.1	50.5
	G. mean²	66.1^a	64.9^a	60.2^a	63.5^a	65.2^a	63.0^a	47.4^a
Sarolaner	Range	0–0	0–0	0–0	0–0	0–0	0–0	0–0
	A. mean	0.0	0.0	0.0	0.0	0.0	0.0	0.0
	Efficacy (%)	100	100	100	100	100	100	100
	G. mean²	0.0^b	0.0^b	0.0^b	0.0^b	0.0^b	0.0^b	0.0^b
	Efficacy (%)	100	100	100	100	100	100	100
	P-value vs. placebo	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
Fluralaner	Range	0–0	0–0	0–0	0–0	0–1	0–17	0–15
	A. mean	0.0	0.0	0.0	0.0	0.1	2.5	2.3
	Efficacy (%)	100	100	100	100	99.8	96.1	95.5
	G. mean²	0.0^b	0.0^b	0.0^b	0.0^b	0.1^b	0.7^b	0.8^b
	Efficacy (%)	100	100	100	100	99.9	98.9	98.4
	P-value vs. placebo	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
	P-value vs. sarolaner	1.000	1.000	1.000	1.0000	0.4040	0.1128	0.0630

¹Sarolaner administered on Days 0, 30, 60; fluralaner on Day 0 only
²Geometric means within columns with the same superscript are not significantly different (P > 0.05)

ISSN: 1756-3305