Table 2 Mean live flea counts and efficacy relative to placebo at 12 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or spinosad/milbemycin oxime on Day 0

Placebo

Range

84–100

19–96

80–100

67–100

80–97

66–98

A. mean

92.0

77.0

87.3

86.6

87.3

81.8

G. mean¹

91.8^a

70.7^a

87.1^a

85.9^a

87.1^a

81.2^a

Sarolaner

Range

0–0

0–0

0–0

0–0

0–0

0–0

A. mean

0.0

0.0

0.0

0.0

0.0

0.0

Efficacy (%)

100

100

100

100

100

100

G. mean¹

0.0^b

0.0^b

0.0^b

0.0^b

0.0^b

0.0^c

Efficacy (%)

100

100

100

100

100

100

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

Spinosad/milbemycin oxime

Range

0–0

0–0

0–0

0–36

0–64

0–68

A. mean

0.0

0.0

0.0

4.5

9.5

27.9

Efficacy (%)

100

100

100

94.8

89.1

65.9

G. mean¹

0.0^b

0.0^b

0.0^b

0.6^b

1.3^b

8.2^b

Efficacy (%)

100

100

100

99.3

98.5

90.0

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

P-value vs. sarolaner

1.000

1.000

1.000

0.2996

0.0538

<0.0001