Table 1 Mean live Rhipicephalus sanguineus sensu lato counts and efficacy relative to placebo at 8 hours after treatment and post-treatment re-infestations for dogs treated with a single oral dose of either sarolaner or afoxolaner on Day 0¹

Placebo

Range

19–43

24–39

16–43

21–40

33–42

28–41

A. mean

32.1

34.1

32.3

32.9

36.5

33.4

G. mean²

31.2^a

33.8^a

31.1^a

32.2^a

36.4^a

33.0^a

Sarolaner

Range

0–15

24–43

19–36

25–42

16–36

26–41

A. mean

3.5

32.3

27.4

31.0

29.8

32.3

Efficacy (%)

89.1

5.5

15.1

5.7

18.5

3.4

G. mean²

1.8^b

31.8^a

26.8^a

30.6^a

29.0^b

31.9^a

Efficacy (%)

94.3

5.8

13.7

5.1

20.2

3.2

P-value vs. placebo

0.0004

0.5773

0.2508

0.6717

0.0390

0.7036

Afoxolaner

Range

3–27

26–48

25–39

26–41

29–34

28–37

A. mean

11.7

34.4

32.4

33.7

31.4

33.0

Efficacy (%)

63.5

0.0

0.0

0.0

13.9

1.1

G. mean²

9.0^c

33.8^a

32.2^a

33.4^a

31.4^b

32.9^a

Efficacy (%)

71.2

0.0

0.0

0.0

13.7

0.4

P-value vs. placebo

0.0070

0.9838

0.7788

0.7690

0.0117

0.9666

P-value vs. sarolaner

0.0238

0.5399

0.0574

0.3106

0.4449

0.6411