Table 3 Mean live Rhipicephalus sanguineus sensu lato counts and efficacy relative to placebo at 24 hours after treatment and post-treatment re-infestations for dogs treated with a single oral dose of either sarolaner or afoxolaner on Day 0¹

Placebo

Range

19–43

17–41

11–34

20–39

24–38

19–37

A. mean

28.8

30.5

26.9

30.0

31.5

28.0

G. mean²

27.8^a

29.5^a

25.6^a

29.2^a

31.2^a

27.3^a

Sarolaner

Range

0–1

0–2

0–3

0–1

0–6

0–11

A. mean

0.1

0.6

1.5

0.3

1.3

3.4

Efficacy (%)

99.6

98.0

94.4

99.2

96.0

87.9

G. mean²

0.1^b

0.5^b

1.1^b

0.2^b

0.7^b

2.3^b

Efficacy (%)

99.7

98.3

95.7

99.4

97.8

91.7

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

0.0001

Afoxolaner

Range

0–0

0–11

2–16

0–15

1–22

11–31

A. mean

0.0

4.1

7.6

8.7

9.6

16.0

Efficacy (%)

100.0

86.4

71.8

71.0

69.6

42.9

G. mean²

0.0^b

3.1^c

6.2^c

6.2^c

7.3^c

15.2^c

Efficacy (%)

100

89.4

76.0

78.8

76.5

44.5

P-value vs. placebo

<0.0001

0.0002

0.0006

0.0078

0.0041

0.0021

P-value vs. sarolaner

0.3833

0.0119

0.0028

0.0022

0.0022

0.0008