Table 1 Efficacy of sarolaner after three monthly treatments on Days 0, 30 and 60 and after a single oral dose of fluralaner on Day 0 against Rhipicephalus sanguineus on dogs 8 h after treatment and re-infestations (AM: arithmetic mean live tick counts; GM: geometric mean live counts)

Placebo

Range

15 to 34

15 to 38

20 to 39

15 to 37

12 to 30

19 to 36

19 to 28

21 to 41

AM

20.5

23.8

32.3

28.0

24.3

28.8

23.9

31.8

GM^d

19.8^a

22.8^a

31.6^a

27.3^a

23.3^a

28.2^a

23.7^a

31.3^a

Sarolaner

Range

0 to 33

11 to 25

9 to 19

9 to 23

11 to 29

17 to 49

8 to 20

21 to 36

AM

6.3

14.5

14.1

14.0

20.0

31.6

12.1

26.8

AM Efficacy (%)

69.5

38.9

56.2

50.0

17.5

0.0

49.2

15.7

GM^d

2.7^b

14.0^b

13.8^b

13.5^b

19.0^a

30.4^a

11.7^b

26.3^a

GM Efficacy (%)

86.6

38.5

56.3

50.6

18.5

0.0

50.8

16.0

P-value vs. placebo

<0.0001

0.0126

<0.0001

0.0003

0.2857

0.6949

0.0004

0.3561

Fluralaner

Range

0 to 10

9 to 17

6 to 16

9 to 24

14 to 28

21 to 34

5 to 23

21 to 39

AM

2.3

13.3

10.0

16.5

23.0

26.0

13.8

25.4

AM Efficacy (%)

89.0

44.2

69.0

41.1

5.2

9.6

42.4

20.1

GM^d

1.3^c

13.0^b

9.5^b

15.7^b

22.5^a

25.6^a

12.8^b

24.9^a

GM Efficacy (%)

93.6

43.0

69.9

42.4

3.4

9.3

46.1

20.3

P-value vs. placebo

<0.0001

0.0050

<0.0001

0.0055

0.8580

0.6132

0.0021

0.2415

P-value vs. sarolaner

0.0433

0.7638

0.1461

0.5413

0.4936

0.4822

0.7219

0.8301