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Table 2 Efficacy of sarolaner after three monthly treatments on Days 0, 30 and 60 and after a single oral dose of fluralaner on Day 0 against Rhipicephalus sanguineus on dogs 12 h after treatment and re-infestations (AM: arithmetic mean live tick counts; GM: geometric mean live counts)

From: Comparative speed of kill of oral treatments with SimparicaTM(sarolaner) and Bravecto®(fluralaner) against induced infestations of Rhipicephalus sanguineus on dogs

Treatment

 

Day of infestation

 

0

14

28

44

58

74

90

95

Placebo

Range

11 to 35

17 to 37

20 to 39

24 to 37

13 to 26

12 to 34

20 to 26

20 to 38

AM

20.8

24.1

31.6

28.3

21.4

26.8

22.3

29.1

GMd

19.7a

23.5a

31.1a

28.0a

20.8a

25.8a

22.2a

28.7a

Sarolaner

Range

0 to 11

2 to 12

7 to 14

5 to 14

9 to 23

12 to 38

5 to 22

20 to 33

AM

1.6

8.0

10.0

10.0

17.0

26.9

12.1

25.5

AM Efficacy (%)

92.2

66.8

68.4

64.6

20.5

0.0

45.5

12.4

GMd

0.6b

7.3b

9.7b

9.6b

16.3a

25.7a

11.1b

25.1a

GM Efficacy (%)

96.8

69.0

68.7

65.7

21.6

0.3

49.8

12.4

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

0.2065

0.9863

0.0005

0.4861

Fluralaner

Range

0 to 2

2 to 11

3 to 10

5 to 19

9 to 24

19 to 32

5 to 17

21 to 29

AM

0.4

5.9

5.8

11.0

16.4

24.4

12.8

24.9

AM Efficacy (%)

98.2

75.6

81.8

61.1

23.4

8.9

42.7

14.6

GMd

0.3b

5.3b

5.3c

9.9b

15.4a

23.9a

12.1b

24.7a

GM Efficacy (%)

98.7

77.5

83.1

64.5

26.1

7.3

45.4

13.7

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

0.1267

0.6959

0.0027

0.4485

P-value vs. sarolaner

0.2720

0.2450

0.0238

0.8946

0.8149

0.7673

0.7431

0.9509

  1. dGeometric means within a counting day with the same superscript are not significantly different (P > 0.05)