Table 3 Efficacy of sarolaner after three monthly treatments on Days 0, 30 and 60 and after a single oral dose of fluralaner on Day 0 against Rhipicephalus sanguineus on dogs 24 h after treatment and re-infestations (AM: arithmetic mean live tick counts; GM: geometric mean live counts)

Placebo

Range

14 to 36

21 to 39

21 to 39

21 to 37

14 to 29

18 to 36

22 to 31

25 to 37

AM

23.5

26.3

28.8

28.0

25.0

29.0

25.8

30.5

GM^d

22.8^a

25.8^a

28.2^a

27.6^a

24.4^a

28.3^a

25.6^a

30.2^a

Sarolaner

Range

0 to 0

0 to 1

0 to 1

0 to 2

0 to 1

1 to 11

0 to 2

0 to 11

AM

0.0

0.3

0.1

0.3

0.3

5.3

0.4

3.8

AM Efficacy (%)

100

99.0

99.6

99.1

99.0

81.9

98.5

87.7

GM^d

0.0^b

0.2^b

0.1^b

0.1^c

0.2^c

4.6^c

0.3^c

2.5^c

GM Efficacy (%)

100

99.3

99.7

99.5

99.2

83.8

99.0

91.9

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

Fluralaner

Range

0 to 0

0 to 3

0 to 1

0 to 5

0 to 8

4 to 27

4 to 20

2 to 32

AM

0.0

1.1

0.1

1.3

3.1

16.8

10.8

14.8

AM Efficacy (%)

100

95.7

99.6

95.5

87.5

42.2

58.3

51.6

GM^d

0.0^b

0.8^b

0.1^b

0.9^b

1.6^b

14.8^b

9.1^b

10.8^b

GM Efficacy (%)

100

96.8

99.7

96.9

93.5

47.9

64.6

64.3

P-value vs. placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

0.0011

<0.0001

<0.0001

P-value vs. sarolaner

1.0000

0.0678

1.0000

0.0415

0.0012

<0.0001

<0.0001

<0.0001