Table 1 The Range, Arithmetic (AM) and Geometric (GM) Mean live Dermacentor reticulatus counts, and efficacy relative to placebo at 8 hours after treatment and re-infestations for dogs treated with either a single oral dose of sarolaner or a single topical application of imidacloprid+permethrin on Day 0

Placebo

Range

23 to 43

12 to 34

26 to 43

13 to 40

21 to 39

20 to 43

AM

33.8

23.5

35.8

28.4

32.4

35.4

GM^c

32.4^a

21.7^a

34.5^a

26.4^a

31.2^a

33.7^a

Sarolaner

Range

0 to 31

6 to 21

8 to 22

12 to 27

13 to 30

12 to 33

AM

8.3

13.1

12.5

19.9

22.1

21.1

AM Efficacy (%)

75.6

44.1

65.0

30.0

31.7

40.3

GM^c

3.4^b

12.1^b

11.6^b

18.6^a

20.6^a

19.8^b

GM Efficacy (%)

89.6

44.1

66.4

29.6

33.9

41.2

P-value vs. placebo

<0.0001

0.0157

<0.0001

0.1349

0.0766

0.0239

Imidacloprid+permethrin

Range

6 to 45

0 to 33

2 to 18

0 to 18

5 to 20

7 to 42

AM

31.9

9.9

8.9

6.9

14.3

19.5

AM Efficacy (%)

5.6

58.0

75.2

75.8

56.0

44.9

GM^c

27.6^a

4.2^c

7.2^b

4.7^b

12.8^b

16.8^b

GM Efficacy (%)

14.6

80.6

79.0

82.0

58.9

50.2

P-value vs. placebo

0.6216

<0.0001

<0.0001

<0.0001

0.0074

0.0331

P-value vs. sarolaner

<0.0001

0.0077

0.2152

0.0005

0.1917

0.6461