Table 1 Mean live Amblyomma americanum counts and efficacy relative to placebo at 8 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0¹

Placebo

Range

4–21

12–32

6–26

11–34

13–36

5–22

A. mean

11.6

21.9

19.1

20.1

26.3

16.5

G. mean²

10.5^a

20.8^a

17.7^a

18.9^a

24.9^a

15.0^a

Sarolaner

Range

5–16

14–24

8–20

11–22

8–34

9–27

A. mean

9.3

19.5

13.0

16.5

17.5

17.3

Efficacy (%)

20.4

10.9

32.0

18.0

33.3

0.0

G. mean²

8.7^a

19.1^a

12.5^a

16.0^a

15.9^a

16.3^a

Efficacy (%)

16.8

8.4

29.5

15.5

36.0

0.0

P-value vs. placebo

0.4573

0.7074

0.1450

0.4773

0.0595

0.7298

Afoxolaner

Range

5–22

8–28

5–21

6–28

8–41

12–26

A. mean

14.7

19.3

12.8

17.3

22.0

18.2

Efficacy (%)

0.0

11.6

32.9

13.9

16.2

0.0

G. mean²

13.0^a

17.9^a

11.4^a

15.1^a

19.0^a

17.2^a

Efficacy (%)

0.0

14.3

35.5

20.1

23.7

0.0

P-value vs. placebo

0.4465

0.5668

0.1130

0.4092

0.3137

0.6098

P-value vs. sarolaner

0.2185

0.8293

0.7795

0.8560

0.5722

0.8543