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Table 1 Mean live Amblyomma americanum counts and efficacy relative to placebo at 8 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 01

From: Comparative speed of kill of sarolaner (Simparica) and afoxolaner (NexGard®) against induced infestations of Amblyomma americanum on dogs

Treatment   Day of treatment or re-infestation
  0 7 14 21 28 35
Placebo Range 4–21 12–32 6–26 11–34 13–36 5–22
A. mean 11.6 21.9 19.1 20.1 26.3 16.5
G. mean2 10.5a 20.8a 17.7a 18.9a 24.9a 15.0a
Sarolaner Range 5–16 14–24 8–20 11–22 8–34 9–27
A. mean 9.3 19.5 13.0 16.5 17.5 17.3
Efficacy (%) 20.4 10.9 32.0 18.0 33.3 0.0
G. mean2 8.7a 19.1a 12.5a 16.0a 15.9a 16.3a
Efficacy (%) 16.8 8.4 29.5 15.5 36.0 0.0
P-value vs. placebo 0.4573 0.7074 0.1450 0.4773 0.0595 0.7298
Afoxolaner Range 5–22 8–28 5–21 6–28 8–41 12–26
A. mean 14.7 19.3 12.8 17.3 22.0 18.2
Efficacy (%) 0.0 11.6 32.9 13.9 16.2 0.0
G. mean2 13.0a 17.9a 11.4a 15.1a 19.0a 17.2a
Efficacy (%) 0.0 14.3 35.5 20.1 23.7 0.0
P-value vs. placebo 0.4465 0.5668 0.1130 0.4092 0.3137 0.6098
P-value vs. sarolaner 0.2185 0.8293 0.7795 0.8560 0.5722 0.8543
  1. 1 n = 6 for afoxolaner, n = 8 for placebo and sarolaner groups
  2. 2Geometric means within columns with the same superscript are not significantly different (P > 0.05)