Table 3 Mean live Amblyomma americanum counts and efficacy relative to placebo at 24 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0¹

Placebo

Range

4–22

14–31

7–33

9–36

17–36

9–26

A. mean

14.1

21.1

22.3

22.0

28.4

20.3

G. mean²

12.6^a

20.2^a

20.1^a

19.9^a

27.4^a

19.1^a

Sarolaner

Range

0–0

0–0

0–2

0–2

0–9

1–20

A. mean

0.0

0.0

0.5

0.4

3.6

8.0

Efficacy (%)

100

100

97.8

98.3

87.2

60.5

G. mean²

0.0^b

0.0^c

0.4^c

0.3^c

2.5^c

5.5^b

Efficacy (%)

100

100

98.2

98.7

91.1

70.9

P-value vs.placebo

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

Afoxolaner

Range

0–0

0–4

0–11

3–16

9–29

10–23

A. mean

0.0

1.5

4.5

9.8

17.7

18.0

Efficacy (%)

100

92.9

79.8

55.3

37.7

11.1

G. mean²

0.0^b

0.9^b

3.0^b

8.5^b

16.1^b

17.0^a

Efficacy (%)

100

95.3

84.9

57.6

41.5

10.6

P-value vs. placebo

<0.0001

<0.0001

<0.0001

0.0025

0.0487

0.6801

P-value vs. sarolaner

0.9525

0.0247

0.0003

<0.0001

<0.0001

0.0007