Skip to main content

Advertisement

Table 3 Mean live Amblyomma americanum counts and efficacy relative to placebo at 24 h after treatment and post-treatment re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 01

From: Comparative speed of kill of sarolaner (Simparica) and afoxolaner (NexGard®) against induced infestations of Amblyomma americanum on dogs

Treatment   Day of treatment or re-infestation
  0 7 14 21 28 35
Placebo Range 4–22 14–31 7–33 9–36 17–36 9–26
A. mean 14.1 21.1 22.3 22.0 28.4 20.3
G. mean2 12.6a 20.2a 20.1a 19.9a 27.4a 19.1a
Sarolaner Range 0–0 0–0 0–2 0–2 0–9 1–20
A. mean 0.0 0.0 0.5 0.4 3.6 8.0
Efficacy (%) 100 100 97.8 98.3 87.2 60.5
G. mean2 0.0b 0.0c 0.4c 0.3c 2.5c 5.5b
Efficacy (%) 100 100 98.2 98.7 91.1 70.9
P-value vs.placebo <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
Afoxolaner Range 0–0 0–4 0–11 3–16 9–29 10–23
A. mean 0.0 1.5 4.5 9.8 17.7 18.0
Efficacy (%) 100 92.9 79.8 55.3 37.7 11.1
G. mean2 0.0b 0.9b 3.0b 8.5b 16.1b 17.0a
Efficacy (%) 100 95.3 84.9 57.6 41.5 10.6
P-value vs. placebo <0.0001 <0.0001 <0.0001 0.0025 0.0487 0.6801
P-value vs. sarolaner 0.9525 0.0247 0.0003 <0.0001 <0.0001 0.0007
  1. 1 n = 6 for afoxolaner, n = 8 for placebo and sarolaner groups
  2. 2Geometric means within columns with the same superscript are not significantly different (P > 0.05)