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Fig. 1 | Parasites & Vectors

Fig. 1

From: The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models

Fig. 1

Development of L. major disease in mice vaccinated with ALM and adjuvants. Groups of 7-8 mice were vaccinated twice with one of the following formulations: PBS; ALM; ALM + CpG; ALM + Pam2; ALM + Pam3 and were subsequently challenged four weeks after the second dose with L. major promastigotes in the right hind foot (RHF). a Lesion development was monitored by measuring the difference in thickness of the infected and uninfected feet (RHF-LHF) in mm; mean values + SEM are shown (* p <0.05; p < 0.005 **; p < 0.0001). b The overall disease severity is summarised by calculating the area under the curve (AUC) from weekly lesion size data sets (mean + SEM is shown). A single experiment was performed, adequately powered to detect a difference of < 40 % between lesion sizes in different groups. For both datasets, normality was observed and thus variance between groups was determined using a one way ANOVA, with Dunnet’s post hoc test to determine differences between test groups and the PBS control (* p <0.05; p < 0.005 **; p < 0.0001)

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