Table 5 Influence of the parasite dose on cutaneous lesion size and the concomitant immune response
From: Study of Leishmania pathogenesis in mice: experimental considerations
Parasite dose | Mouse strain | Parasite strain | Lesion size (footpad) | Th1 response | Th2 response | Reference |
|---|---|---|---|---|---|---|
101 | BALB/c | MHOM/IL/80/Friedlin | +/- | +++ | +/- | [69] |
BALB/c | MHOM/IR/-/173 | +/- | ND | ND | [67] | |
102 | BALB/c | MHOM/IL/80/Friedlin | +/- | ND | ND | [68] |
BALB/c | MHOM/IL/80/Friedlin | - | ++ | +/- | [67] | |
BALB/c | MHOM/IR/-/173 | + | ++ | +/- | [67] | |
BALB/c | MHOM/IL/80/Friedlin | + | + | - | [69] | |
BALB/c | MHOM/IR/-/173 | +/- | ++ | - | [70] | |
C57BL/6 | MHOM/IR/-/173 | - | [70] | |||
103 | BALB/c | MHOM/IL/80/Friedlin | + | - | +/- | [68] |
BALB/c | MHOM/IL/80/Friedlin | - | ND | ND | [67] | |
BALB/c | MHOM/IL/80/Friedlin | ++ | + | + | [69] | |
BALB/c | MHOM/IR/-/173 | + | ND | ND | [70] | |
C57BL/6 | MHOM/IL/80/Friedlin | + | + | ++ | [71] | |
C57BL/6 | MHOM/IR/-/173 | - | ND | ND | [70] | |
104 | BALB/c | MHOM/IL/80/Friedlin | +/++ | ND | ND | [68] |
BALB/c | MHOM/IL/80/Friedlin | + | ND | ND | [67] | |
BALB/c | MHOM/IR/-/173 | ++ | ND | ND | [67] | |
BALB/c | MHOM/IL/80/Friedlin | ++ | +/- | + | [69] | |
BALB/c | MHOM/IR/-/173 | + | ND | ND | [70] | |
C57BL/6 | MHOM/IR/-/173 | +/- | ND | ND | [70] | |
105 | BA[71]LB/c | MHOM/IL/80/Friedlin | ++ | ND | ND | [68] |
BALB/c | MHOM/IL/80/Friedlin | +++ | +/- | ++ | [69] | |
BALb/c | MHOM/IR/-/173 | + | ND | ND | [70] | |
C57BL/6 | MHOM/IR/-/173 | +/- | ND | ND | [70] | |
106 | BALB/c | MHOM/IL/80/Friedlin | +++ | - | ++ | [68] |
BALB/c | MHOM/IL/80/Friedlin | ++ | ND | ND | [67] | |
BALB/c | MHOM/IL/(0/Friedlin | +++ | +/- | +++ | [69] | |
BALB/c | MHOM/IR/-/173 | ++ | + | + | [70] | |
C57BL/6 | MHOM/IL/80/Friedlin | + | ++ | - | [71] | |
C57BL/6 | MHOM/IR/-/173 | + | ++ | - | [70] | |
107 | BALB/c | MHOM/IL/80/Friedlin | ++++ | +/- | ++ | [68] |
BALB/c | MHOM/IL/80/Friedlin | +++ | +/- | ++ | [67] | |
BALB/c | MHOM/IR/-/173 | ++ | ND | ND | [70] | |
C57BL/6 | MHOM/IR/-/173 | + | ND | ND | [70] |