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Table 2 Comparison of the numbers of ion channel sequences within each family among humans, C. elegans and representative parasitic flatworms* that were classified with high and medium confidence

From: Pipeline for the identification and classification of ion channels in parasitic flatworms

Ion channel family Hs Ce Trematoda Cestoda
Ov Cs Sh Sj Sm Eg Em Ts
Cys-loop superfamily 46 36 3 2 4 5 4 6 6 7
Glutamate-gated cation channels 18 8 4 6 6 0 4 5 5 5
Epithelial and related channels 16 0 3 2 1 3 4 2 2 3
Ryanodine and IP3 receptors 6 2 1 1 1 1 2 1 1 0
Voltage-gated ion channels 114 22 16 15 14 11 16 12 13 7
Related to voltage-gated ion channels 66 14 10 13 9 6 12 9 8 7
Chloride channels 19 7 2 2 2 3 3 3 3 1
Aquaporins 14 4 2 3 1 2 2 0 0 0
Unclassified ion channel-like proteins - - 73 54 69 88 40 38 44 65
Total 299 93 114 98 107 119 87 82 82 95
  1. *Hs Homo sapiens, Ce Caenorhabditis elegans, Ov Opisthorchis viverrini, Cs Clonorchis sinensis, Sh Schistosoma haematobium, Sj Schistosoma japonicum, Sm Schistosoma mansoni, Eg Echinococcus granulosus, Em Echinococcus multilocularis, Ts Taenia solium