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Fig. 2 | Parasites & Vectors

Fig. 2

From: Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei

Fig. 2

Template-based model. Domain organization and homology model of the REG-CAT region of TbPARP, with nicotinamide (NI) and adenosine (ADE) binding pockets of the substrate NAD+ labelled. The inset shows how 4-ANI binds to the binding site of nicotinamide (built from the chicken PARP superposition PDB code 2PAX [56]). Residues around the NI site and at the REG domain are shown for TbPARP (grey) and 2PAX (human PARP-1 numbering, blue)

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Parasites & Vectors

ISSN: 1756-3305

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