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Table 2 Erythrogram of control hamsters and hamsters experimentally infected with strains PP75 and OP46 of L. infantum

From: Clinical, hematological and biochemical alterations in hamster (Mesocricetus auratus) experimentally infected with Leishmania infantum through different routes of inoculation

Hematological variables by group

Time/months

1

3

6

9

1

3

6

9

C group

        

 Erythrocytes (106/mm3)

7.2 ± 0.3

7.2 ± 1.1

8.5 ± 1.2

8.4 ± 1.0

7.4 ± 0.4

7.0 ± 0.3

7.1 ± 0.2

6.7 ± 0.3

 Hemoglobin (g/dL)

13.9 ± 0.6

13.5 ± 0.8

17.6 ± 2.1

17.5 ± 2.3

15.0 ± 1.0

13.3 ± 0.9

13.3 ± 0.5

13.2 ± 0.7

 Hematocrit (%)

35.5 ± 3.6

34.6 ± 7.2

39.5 ± 5.5

38.4 ± 6.7

32.6 ± 1.5

30.5 ± 2.3

32.5 ± 2.3

33.2 ± 2.0

 Platelets (106/mm3)

165.8 ± 37.4

142.6 ± 33.8

154.9 ± 143

127.4 ± 12.5

139.9 ± 20.8

136.4 ± 16.9

164.7 ± 15.5

174.0 ± 20.5

 

Strain/months after infection

PP75 strain

OP46 strain

1

3

6

9

1

3

6

9

ID group

        

 Erythrocytes (106/mm3)

6.5 ± 0.4

7.2 ± 0.2

6.5 ± 0.4a

8.5 ± 0.7

7.4 ± 0.3

6.8 ± 0.3

6.7 ± 0.8

6.9 ± 0.3

 Hemoglobin (g/dL)

13.7 ± 1.1

13.6 ± 0.5

12.7 ± 1.0a

19.7 ± 4.5

15.2 ± 0.6

13.3 ± 0.7

12.6 ± 1.6

13.7 ± 0.3

 Hematocrit (%)

29.3 ± 2.1a

36.3 ± 3.0

31.1 ± 2.7a

38.3 ± 3.9

33.9 ± 1.5

31.2 ± 3.0

33.6 ± 3.6

34.0 ± 2.0

 Platelets (106/mm3)

123.8 ± 16.2

168.70 ± 25.26

138.3 ± 19.2

108.1 ± 18.0

156.8 ± 27.5

141.1 ± 24.4

185.5 ± 24.4

189.4 ± 27.3

IP group

        

 Erythrocytes (106/mm3)

6.1 ± 0.1

6.8 ± 0.7

6.7 ± 0.2a

9.8 ± 0.5a,b

7.5 ± 1.0

7.1 ± 0.4

7.0 ± 0.5

6.2 ± 1.0

 Hemoglobin (g/dL)

13.4 ± 0.5

13.1 ± 1.2

13.4 ± 0.4a

21.2 ± 1.3

14.4 ± 0.6

13.6 ± 1.2

12.8 ± 1.1

12.0 ± 2.0

 Hematocrit (%)

28.9 ± 1.5a

38.7 ± 3.2

31.2 ± 2.7a

43.9 ± 2.2

32.0 ± 2.6

31.4 ± 3.2

36.1 ± 2.6

31.0 ± 4.2

 Platelets (106/mm3)

134.1 ± 45.3

221.6 ± 75.0a

132.2 ± 23.4

126.3 ± 14.5

169.3 ± 35.4

145.6 ± 32.1

184.4 ± 32.7

174.6 ± 87.4

IC group

        

 Erythrocytes (106/mm3)

6.6 ± 0.4

7.2 ± 0.7

6.8 ± 0.3a

9.2 ± 1.0

7.1 ± 0.4

6.7 ± 0.3

4.3 ± 1.4a,b,c

4.7 ± 1.9a,b, c

 Hemoglobin (g/dL)

13.7 ± 0.8

13.8 ± 1.2

13.6 ± 0.7a

20.0 ± 2.4

14.5 ± 0.9

12.3 ± 1.6

7.0 ± 1.8a,b,c

10.1 ± 4.2a,b

 Hematocrit (%)

30.1 ± 1.8a

35.0 ± 3.6

31.5 ± 2.4a

41.5 ± 4.3

31.6 ± 2.1

29.0 ± 4.4

21.0 ± 6.9a,b,c

25.0 ± 9.4a,b

 Platelets (106/mm3)

134.1 ± 21.5

144.6 ± 22.3c

135.4 ± 13.5

108.5 ± 17.5

156.5 ± 17.0

110.9 ± 29.8

329.4 ± 153.5a,b,c

291.3 ± 136.4a,b,c

  1. Values (mean ± standard deviation) erytrogram of uninfected hamsters as a control group (C) and infected animals with strains PP75 and OP46 of L. infantum by different routes of inoculation: intradermal (ID), intraperitoneal (IP), intracardiac (IC). Significant differences (P < 0.05) are represented by letters a, b, crelated to the C, ID and IP groups respectively