Patient | Serotype | Serum virus titre (log10 RNAcopy/ml) | Mode of infection | Feeding rate fed/n (%) | P-valuea | Midgut | Salivary Glands | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Infected/n (% infection)b | Number of RNA copies | P-valuea | infected/n (% infection)b | DENV SG Titer (Log10TCID50/ml) | P-valuea | ||||||
5 | 1 | 9.49 | DSFA | 30/30 (100) | <0.0001* | 100 (12) | 9.07 ± 0.26 | 0.95 | 12/12 (100) | 4.98 ± 1.03 | 0.16 |
MFA | 37/56 (66) | 100 (12) | 9.11 ± 0.13 | 12/12 (100) | 5.52 ± 0.66 | ||||||
8 | 1 | 9.21 | DSFA | 30/30 (100) | <0.0001* | 9/9 (100) | 9.16 ± 0.09 | 0.02* | 9/9(100) | 4.67 ± 0.94 | 0.02* |
MFA | 27/56 (48.2) | 12/12 (100) | 8.45 ± 0.54 | 12/12(100) | 5.24 ± 0.28 | ||||||
9 | 1 | 5.65 | DSFA | 27/30 (90) | 0.03* | 12/12 (100) | 3.62 ± 1.93 | 0.88 | 0/12 | 0 | ND |
MFA | 38/56 (67.8) | 8/12 (66.7) | 4.57 ± 3.10 | 0/12 | 0 | ||||||
10 | 1 | 4.76 | DSFA | 30/30 (100) | 0.007* | 2/12 (16.7) | 3.52 | ND | 0/12 | 0 | ND |
MFA | 45/56 (80.4) | 2/12 (16.7) | 3.08 | 0/12 | 0 | ||||||
11 | 1 | 7.51 | DSFA | 29/30 (96.7) | 0.25 | 12/12 (100) | 6.22 ± 2.96 | 0.52 | 6/12 (50) | 3.95 ± 0.7 | 0.09 |
MFA | 49/56 (87.5) | 12/12 (100) | 6.38 ± 3.3 | 5/12 (42) | 4.95 ± 0.76 | ||||||
12 | 1 | 9.18 | DSFA | 28/30 (93.3) | 1 | 12/12 (100) | 9.8 ± 0.48 | 0.52 | 12/12 (100) | 5.18 ± 0.49 | 0.003 |
MFA | 51/56 (91.1) | 12/12 (100) | 9.66 ± 0.31 | 8/12 (67) | 4.74 ± 1.66 | ||||||
13 | 1 | 8.44 | DSFA | 17/17 (100) | 0.57 | 12/12 (100) | 9.69 ± 0.37 | 0.06 | 11/12 (92) | 3.52 ± 1.19 | 0.82 |
MFA | 43/47 (91.5) | 12/12 (100) | 9.73 ± 1.51 | 12/12 (100) | 4.89 ± -.66 | ||||||
14 | 1 | 5.71 | DSFA | 17/17 (100) | 0.001* | 7/12 (58.3) | 3.25 ± 1.12 | 1 | 0/12 | 0 | ND |
MFA | 27/46 (58.7) | 8/12 (66.7) | 2.83 ± 0.2 | 0/12 | 0 | ||||||
15 | 1 | 5.64 | DSFA | 16/17 (94.1) | 0.66 | 11/11 (100) | 5.21 ± 3.00 | 0.14 | 3/12 (27) | 4.19 ± 0.57 | ND |
MFA | 37/42 (88.1) | 9/12 (75) | 3.87 ± 2.01 | 1/11 (9) | 3.95 | ||||||
16 | 1 | 8.85 | DSFA | 17/17 (100) | 1 | 12/12 (100) | 9.50 ± 0.11 | 0.02* | 12/12 (100) | 4.64 ± 0.49 | 0.8 |
MFA | 46/46 (100) | 12/12 (100) | 9.66 ± 0.17 | 12/12 (100) | 4.34 ± 0.67 | ||||||
17 | 1 | 4.75 | DSFA | 17/17 (100) | 0.02* | 8/12 (66.7) | 2.62 ± 0.01 | 0.16 | 0/12 | 0 | ND |
MFA | 40/56 (71.4) | 7/12 (58.3) | 3.48 ± 0.82 | 0/12 | 0 | ||||||
18 | 1 | 7.55 | DSFA | 17/17 (100) | 0.03* | 12/12 (100) | 7.6 ± 3.68 | 0.06 | 1/12 (8) | 4.95 | ND |
MFA | 42/56 (75) | 12/12 (100) | 5.44 ± 3.29 | 6/12 (50) | 3.73 ± 0.30 | ||||||
19 | 1 | 7.31 | DSFA | 17/17 (100) | 0.02* | 10/12 (83.3) | 5.9 ± 3.26 | 0.45 | 5/12 (45) | 4.69 ± 0.74 | 0.76 |
MFA | 39/54 (72.2) | 10/11 (90.9) | 6.89 ± 3.17 | 3/12 (25) | 4.52 ± 1.00 | ||||||
20 | 1 | 8.2 | DSFA | 17/17 (100) | 0.32 | 12/12 (100) | 9.66 ± 0.24 | 0.15 | 12/12 (100) | 4.25 ± 0.49 | 0.54 |
MFA | 50/56 (89.3) | 12/12 (100) | 9.51 ± 0.18 | 12/12 (100) | 4.36 ± 0.52 | ||||||
21 | 1 | 8.79 | DSFA | 17/17 (100) | 0.19 | 12/12 (100) | 8.86 ± 0.72 | 0.4529 | 12/12 (100) | 4.22 ± 0.41 | 0.63 |
MFA | 49/56 (87.5) | 12/12 (100) | 9.12 ± 0.22 | 12/12 (100) | 4.26 ± 0.59 | ||||||
22 | 1 | 8.84 | DSFA | 17/17 (100) | 0.02* | 12/12 (100) | 9.17 ± 0.12 | 0.05 | 12/12 (100) | 5.02 ± 0.34 | 0.033 |
MFA | 40/56 (71.4) | 12/12 (100) | 9.37 ± 0.27 | 12/12 (100) | 4.52 ± 0.65 | ||||||
23 | 1 | 9.39 | DSFA | 17/17 (100) | 0.58 | 12/12 (100) | 9.05 ± 0.21 | 0.1489 | 12/12 (100) | 3.58 ± 0.71 | 0.42 |
MFA | 51/56 (91.1) | 12/12 (100) | 9.14 ± 0.41 | 12/12 (100) | 3.9 ± 0.44 | ||||||
24 | 1 | 6.31 | DSFA | 17/17 (100) | 0.17 | 12/12 (100) | 5.58 ± 2.83 | 0.8399 | 3/12 (17) | 3.84 ± 1.33 | ND |
MFA | 42/56 (75) | 12/12 (100) | 6.1 ± 2.85 | 6/12 (50) | 4.40 ± 0.39 | ||||||
25 | 1 | 8.12 | DSFA | 17/17 (100) | 1 | 12/12 (100) | 9.26 ± 0.46 | 0.5637 | 12/12 (100) | 4.75 ± 0.58 | 0.29 |
MFA | 55/58 (94.8) | 12/12 (100) | 9.34 ± 0.26 | 12/12 (100) | 4.48 ± 0.46 | ||||||
26 | 1 | 8.03 | DSFA | 17/17 (100) | 1 | 12/12 (100) | 9.03 ± 0.34 | 0.3865 | 12/12 (100) | 4.99 ± 0.50 | 0.4 |
MFA | 55/56 (98.2) | 12/12 (100) | 8.16 ± 2.26 | 10/12 (83) | 5.15 ± 0.41 | ||||||
4 | 2 | 5.6 | DSFA | 29/30 (96.7) | 1 | 7/12 (58.3) | 3.46 ± 2.34 | 1 | 1/12(8.3) | 4.52 | ND |
MFA | 55/56 (98) | 7/12 (58.3) | 3.52 ± 2.12 | 1/12(8.3) | 2.52 | ||||||
7 | 2 | 3.73 | DSFA | 29/29 (100) | 0.09 | 11/12 (91.7) | 3.04 ± 0.52 | 0.21 | 0/12 | 0 | ND |
MFA | 51/58 (87.9) | 9/12 (75) | 3.42 ± 0.65 | 0/12 | 0 | ||||||
1 | 3 | 3.69 | DSFA | 30/30 (100) | 0.15 | 1/12 (8.3) | 2.47 | ND | 0/12 | 0 | ND |
MFA | 47/56 (83.9) | 2/12 (16.7) | 3.11 | 0/12 | 0 | ||||||
2 | 3 | 3.94 | DSFA | 30/30 (100) | <0.0001* | 3/12 (25) | 1.68 ± 0.38 | ND | 0/12 | 0 | ND |
MFA | 39/59 (69.6) | 2/12 (16.7) | 1.41 | 0/12 | 0 | ||||||
3 | 3 | 8.69 | DSFA | 30/30 (100) | 0.0001* | 12/12 (100) | 9.23 ± 0.18 | 0.15 | 12/12 (100) | 5.22 ± 1.26 | 0.16 |
MFA | 40/60 (66.7) | 12/12 (100) | 9.34 ± 0.18 | 12/12 (100) | 4.54 ± 1.14 |