Table 2 Relative sterol content of a recently isolated virulent (vir) strain compared to an avirulent (L5) strain of Leishmania infantum
From: Dynamics of sterol synthesis during development of Leishmania spp. parasites to their virulent form
Parasite-growth phase | L5-LOG (n = 2) | Vir-LOG (n = 3) | L5-STAT (n = 5) | Vir-STAT (n = 11) | L5-STAT (n = 3) | Vir-STAT (n = 3) |
|---|---|---|---|---|---|---|
Growth Medium | HOMEM | SFM | ||||
Sterol: | ||||||
Cholesterol | 16.68 (3.70) | 14.60 (0.38) | 33.69 (5.25) | 27.77 (7.94) | 1.14 (0.13) | 3.69 (4.28) |
Zymosterol | 0.00 (0.00) | 0.00 (0.00) | 0.27 (0.38) | 0.71 (2.17) | 0.72 (0.63) | 2.52 (2.25) |
Ergosterol -I | 28.68 (6.48) | 30.92 (3.73) | 18.99 (3.85) | 19.09 (7.59) | 22.96 (3.09) | 34.70* (5.98) |
Ergosta-7,22-dien-3β-ol - I | 5.62 (6.48) | 4.76 (3.74) | 2.29 (1.58) | 5.50 (4.64) | 2.16 (1.94) | 1.64 (1.33) |
Ergostatetraenol | 3.27 (4.62) | 3.38 (3.57) | 1.92 (1.72) | 0.72 (1.25) | 1.97 (1.80) | 3.39 (2.39) |
Ergosterol -II | 39.93 (2.62) | 39.13 (1.37) | 39.28 (5.81) | 21.74** (11.33) | 50.17 (5.33) | 31.33* (8.09) |
Ergosta-7,22-dien-3β-ol- II | 1.71 (0.04) | 6.58* (1.20) | 0.84 (0.66) | 20.66*** (9.43) | 12.69 (9.50) | 12.56 (7.28) |
Lanosterol | 0.00 (0.00) | 0.00 (0.00) | 0.16 (0.36) | 0.15 (0.35) | 1.14 (1.07) | 0.58 (1.00) |
Stigmasta-7,24(28)-dien-3β-ol | 4.10 (5.80) | 0.63 (0.32) | 2.50 (3.44) | 3.65 (1.88) | 4.77 (2.50) | 9.60 (5.17) |