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Table 1 IC50 values (μM ± SEM) for inhibition of dopamine-stimulated IP1 response in HEK-293 cell lines by DAR antagonists

From: Comparative pharmacological characterization of D1-like dopamine receptors from Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus suggests pleiotropic signaling in mosquito vector lineages

Compound AgDOP2 AaDOP2 CqDOP2 Fold selectivity to AgDOP2
AaDOP2 CqDOP2
Amitriptyline 0.23 ± 0.02 0.05 ± 0.003 0.08 ± 0.007 4.4 3.0
Amperozide 18.8 ± 11 5.1 ± 1 2.6 ± 0.6 3.7 7.2
Asenapine 0.0007 ± 0.00008 0.003 ± 0.0005 0.02 ± 0.004 0.3 0.05
Butaclamol 1.2 ± 0.4 1.0 ± 0.2 2.8 ± 0.9 1.2 0.4
Chlorprothixene 0.4 ± 0.007 0.04 ± 0.01 0.01 ± 0.002 0.9 3.2
Methiothepin 0.14 ± 0.008 0.003 ± 0.001 0.01 ± 0.005 4.1 1.1
SCH23390 3.6 ± 0.8 4.7 ± 0.8 8.3 ± 1 0.8 0.4