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Table 1 IC50 values (μM ± SEM) for inhibition of dopamine-stimulated IP1 response in HEK-293 cell lines by DAR antagonists

From: Comparative pharmacological characterization of D1-like dopamine receptors from Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus suggests pleiotropic signaling in mosquito vector lineages

Compound

AgDOP2

AaDOP2

CqDOP2

Fold selectivity to AgDOP2

AaDOP2

CqDOP2

Amitriptyline

0.23 ± 0.02

0.05 ± 0.003

0.08 ± 0.007

4.4

3.0

Amperozide

18.8 ± 11

5.1 ± 1

2.6 ± 0.6

3.7

7.2

Asenapine

0.0007 ± 0.00008

0.003 ± 0.0005

0.02 ± 0.004

0.3

0.05

Butaclamol

1.2 ± 0.4

1.0 ± 0.2

2.8 ± 0.9

1.2

0.4

Chlorprothixene

0.4 ± 0.007

0.04 ± 0.01

0.01 ± 0.002

0.9

3.2

Methiothepin

0.14 ± 0.008

0.003 ± 0.001

0.01 ± 0.005

4.1

1.1

SCH23390

3.6 ± 0.8

4.7 ± 0.8

8.3 ± 1

0.8

0.4