Fig. 3

Serum-specific IgG antibody levels by ELISA during vaccination trials against nFh12, rFh15 or rFh15b. Data presented as the mean ± standard error of the mean. BALB/c mice were vaccinated with their respective antigens formulated with the adjuvant adaptation (ADAD) vaccination system with the natural immunomodulator PAL or the synthetic AA0029 and challenged with 150 cercariae of S. mansoni. a Vaccination using nFh12 formulated with PAL; b Vaccination with rFh15 using PAL; c Vaccination using rFh15 or rFh15b formulated with AA0029. O.D., optical densities; *P < 0.05 compared to uninfected controls