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Table 2 Cytokine production (TNF-α, IL-6, IL-1α IFNγ, IL-2, IL-4, IL-10, IL-17) in supernatants of splenocyte cultures in untreated BALB/c mice, treated with AA0029+Qs and immunised with AA0029+Qs+rFh15 and AA0029+Qs+rFh15b 2 weeks after immunisation schedule. Data are presented as the mean ± standard error of the mean. Kruskal-Wallis χ 2, degrees of freedom (df) and P-values, and P-values in case of significant differences in pairwise comparisons

From: Protection against Schistosoma mansoni infection using a Fasciola hepatica-derived fatty acid binding protein from different delivery systems

Cytokine Untreated AA0029+Qs AA0029+Qs+rFh15 AA0029+Qs+rFh15b Kruskal-Wallis
  (pg/ml) (pg/ml) (pg/ml) (pg/ml) χ 2 df P
TNFα 313 ± 98 214 ± 20 937 ± 130 1,074 ± 89 16.22 3 0.001
P = 0.001a P = 0.001a
IL-6 964 ± 118 1,318 ± 137 2,755 ± 226 1,613 ± 137 17.11 3 0.001
P = 0.001a P = 0.001a
P < 0.001b
IL-1α 527 ± 65 368 ± 32 448 ± 23 581 ± 142    
IFNγ 543 ± 35 643 ± 16 735 ± 23 890 ± 79 20.40 3 < 0.001
P < 0.001a
P < 0.001b
IL-2 592 ± 74 774 ± 84 1,025 ± 47 888 ± 41 10.27 3 0.016
P < 0.001a P = 0.001a
IL-4 1,138 ± 101 1,508 ± 82 2,078 ± 145 1,653 ± 18 16.91 3 <0.001
P < 0.001a P < 0.001a
IL-10 481 ± 46 485 ± 39 424 ± 7 459 ± 21    
IL-17 1,724 ± 167 2,048 ± 43 2,053 ± 46 1,988 ± 268    
  1. aSignificant differences in comparison with untreated group; bSignificant differences compared to AA0029+Qs+rFh15 vaccinated group