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Table 2 Kinetics of laboratorial alterations at the time of diagnosis and during treatment. The median values ± interquartile range of laboratorial parameters at every point of the study

From: Early reduction of Leishmania infantum-specific antibodies and blood parasitemia during treatment in dogs with moderate or severe disease

Parameters (units) Reference intervalsg Day 0 Day 30 Day 180 Day 365
UPC ratioa < 0.5 0.3 ± 0.7 0.2 ± 0.2 0.2 ± 0.5 0.1 ± 0.3
Total protein (g/dl)b 5.4–7.1 8.00 ± 3.05 7.08 ± 1.60 6.63 ± 0.67 6.70 ± 0.65
Albumin (g/dl)c 2.6–3.3 2.66 ± 0.89 2.72 ± 0.65 3.33 ± 0.54 3.36 ± 0.53
Gamma-globulins (g/dl)d 0.3–0.8 1.63 ± 3.03 0.91 ± 1.11 0.63 ± 0.28 0.61 ± 0.33
Hematocrit (%)e 40–61 36 ± 13 39 ± 10 44 ± 7 46 ± 9
Hemoglobin (g/dl)f 13.0–19.8 12.6 ± 4.2 13.7 ± 3.1 15.8 ± 2.6 16.3 + 4.0
  1. aComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test, Z = -2.987 P = 0.003), day 180 (Z = -2.521 P = 0.012), day 365 (Z = -2.500 P = 0.012)]. Comparison between day 30 - day 180 (Z = -0.456, P = 0.649), day 30 - day 365 (Z = -0.533, P = 0.594) and day 180 - day 365 (Z = -1.122, P = 0.262)
  2. bComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test: Z = -3.676, P = 0.000237), day 180 (Z = -3.784, P = 0.000155) and day 365 (Z = -3.579, P = 0.000345)]. Comparison between day 30 - day 180 (Z = -2.707, P = 0.007), day 30 - day 365 (Z = -2.033, P = 0.042) and day 180 - day 365 (Z = -0.205, P = 0.83)
  3. cComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test: Z = -2.040, P = 0.041), day 180 (Z = -5.004, P < 0.0001) and day 365 (Z = -4.703, P < 0.0001)]. Comparison between day 30 - day 180 (Z = -4.342, P < 0.0001), day 30 - day 365 (Z = -3.530, P < 0.0001) and day 180 - day 365 (Z = -0.573, P = 0.566)
  4. dComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test: Z = -4116, P < 0.0001), day 180 (Z = -4.357, P < 0.0001) and day 365 (Z = -2.084, P = 0.037)]. Comparison between day 30 - day 180 (Z = -3.752, P = 0.000175), day 30 - day 365 (Z = -4.065, P < 0.0001) and day 180 - day 365 (Z = -0.379, P = 0.705)
  5. eComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test: Z = -2.655, P = 0.008), day 180 (Z = -4.379, P < 0.0001) and day 365 (Z = -3.977, P < 0.0001)]. Comparison between day 30 - day 180 (Z = -2.657, P = 0.008), day 30 - day 365 (Z = -3.322, P = 0.020) and day 180 - day 365 (Z = -1.202, P = 0.229)
  6. fComparison between day 0 and the other days [day 30 (Wilcoxon signed-rank test: Z = -2.806, P = 0.005), day 180 (Z = -4.243, P < 0.0001) and day 365 (Z = -3.521, P = 0.000431)]. Comparison between day 30 - day 180 (Z = -3.181, P = 0.001), day 30 - day 365 (Z = -3.124, P = 0.002) and day 180 - day 365 (Z = -1.384, P = 0.166)
  7. gUAB hematological and biochemical laboratory reference intervals