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Table 2 Mean tick counts and efficacy (%) after a single topical fluralaner administration (Bravecto™ spot-on solution) against Rh. sanguineus infestations in dogs

From: Efficacy of fluralaner spot-on solution against induced infestations with Rhipicephalus sanguineus on dogs

Assessment time points a

Study day 2

Study day 30

Study day 58

Study day 86

Study

Fluralaner

Control

Fluralaner

Control

Fluralaner

Control

Fluralaner

Control

1

Meanb tick counts (n)

1.8 (3.8)

20.5 (25.1)

0 (0)

29.1 (29.8)

0 (0)

32.6 (32.9)

0 (0)

33.8 (34.0)

Count range (n)

0–19

4e–44

0

20–39

0

26–39

0

29–39

Efficacyc (%)

91.1 (84.9) d

100 (100) d

100 (100) d

100 (100) d

P-value

0.0004

< 0.0001

< 0.0001

< 0.0001

2

Meanb tick counts (n)

0 (0)

18.7 (19.9)

0 (0)

13.8 (16.5)

0 (0)

24.7 (26.3)

0.1 (0.1)

34.2 (35.8)

Count range (n)

0

10f–34

0

3f–34

0

16–37

0–1

26–67

Efficacy c (%)

100 (100) d

100 (100) d

100 (100) d

100 (100) d

P-value

< 0.0001

< 0.0001

< 0.0001

< 0.0001

3

Meanb tick counts (n)

0 (0)

10.4 (14.3)

0 (0)

24.3 (25.5)

0 (0)

15.7 (17.9)

0 (0)

19.8 (23.3)

Count range (n)

0

4g–37

0

14–38

0

6g–26

0

6g–35

Efficacy c (%)

100 (100) d

100 (100) d

100 (100) d

100 (100) d

P-value

< 0.0001

< 0.0001

< 0.0001

< 0.0001

4

Meanb tick counts (n)

0.9 (2.8)

37.4 (38.6)

0 (0)

26.1 (27.7)

0.2 (0.3)

18.1 (19.6)

0.6 (1.1)

19.4 (20.8)

Count range (n)

0–23

24–51

0

16–41

0–2

8h–33

0–5

12h–32

Efficacy c (%)

97.6 (92.7) d

100 (100) d

98.9 (98.5) d

96.7 (94.7) d

P-value

< 0.001

< 0.001

< 0.001

< 0.001

5

Meanb tick counts (n)

0.7 (1.8)

21.1 (25.0)

0 (0)

26.4 (26.9)

0 (0)

28.8 (29.8)

0.1 (0.1)

22.3 (23.1)

Count range (n)

0–11

2i–40

0

19–37

0

18–43

1–0

13–33

Efficacy c (%)

96.6 (92.8) d

100 (100) d

100 (100) d

99.7 (99.6) d

P-value

≤ 0.001

≤ 0.001

≤ 0.001

≤ 0.001

6

Meanb tick counts (n)

0.1 (0.1)

30.4 (30.8)

0.1 (0.1)

24.0 (24.5)

0.1 (0.1)

17.6 (18.7)

0.0 (0.0)

17.8 (18.3)

Count range (n)

0–1

21–38

0–1

18–31

0–1

12j–33

0

11j–25

Efficacy c (%)

99.8 (99.7) d

99.7 (99.6) d

99.6 (99.5) d

100 (100) d

P-value

< 0.001

< 0.001

< 0.001

< 0.001

  1. aAssessment of ticks 48 h (± 4 h) after treatment or re-infestation following treatment; bGeometric mean (arithmetic mean); cCalculated based on geometric mean (arithmetic mean); dLog-counts of live ticks from the treatment group were significantly different (P ≤ 0.05) from log-counts of the respective untreated control group
  2. e eight from ten dogs adequately infested; f seven from eight dogs adequately infested (Study day (SD) 2), five from eight dogs adequately infested (SD 30); g four from eight dogs adequately infested (SD 2), six from eight dogs adequately infested (SD 58), six from eight dogs adequately infested (SD 86); h eight from ten dogs adequately infested (Study day (SD) 58 and SD 86): i nine from ten dogs adequately infested (Study day (SD) 2); j eight from ten dogs adequately infested (SD58), nine from ten dogs adequately infested (SD86)