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Table 2 Mean tick counts and efficacy (%) after a single topical fluralaner administration (Bravecto™ spot-on solution) against Rh. sanguineus infestations in dogs

From: Efficacy of fluralaner spot-on solution against induced infestations with Rhipicephalus sanguineus on dogs

Assessment time points a Study day 2 Study day 30 Study day 58 Study day 86
Study Fluralaner Control Fluralaner Control Fluralaner Control Fluralaner Control
1 Meanb tick counts (n) 1.8 (3.8) 20.5 (25.1) 0 (0) 29.1 (29.8) 0 (0) 32.6 (32.9) 0 (0) 33.8 (34.0)
Count range (n) 0–19 4e–44 0 20–39 0 26–39 0 29–39
Efficacyc (%) 91.1 (84.9) d 100 (100) d 100 (100) d 100 (100) d
P-value 0.0004 < 0.0001 < 0.0001 < 0.0001
2 Meanb tick counts (n) 0 (0) 18.7 (19.9) 0 (0) 13.8 (16.5) 0 (0) 24.7 (26.3) 0.1 (0.1) 34.2 (35.8)
Count range (n) 0 10f–34 0 3f–34 0 16–37 0–1 26–67
Efficacy c (%) 100 (100) d 100 (100) d 100 (100) d 100 (100) d
P-value < 0.0001 < 0.0001 < 0.0001 < 0.0001
3 Meanb tick counts (n) 0 (0) 10.4 (14.3) 0 (0) 24.3 (25.5) 0 (0) 15.7 (17.9) 0 (0) 19.8 (23.3)
Count range (n) 0 4g–37 0 14–38 0 6g–26 0 6g–35
Efficacy c (%) 100 (100) d 100 (100) d 100 (100) d 100 (100) d
P-value < 0.0001 < 0.0001 < 0.0001 < 0.0001
4 Meanb tick counts (n) 0.9 (2.8) 37.4 (38.6) 0 (0) 26.1 (27.7) 0.2 (0.3) 18.1 (19.6) 0.6 (1.1) 19.4 (20.8)
Count range (n) 0–23 24–51 0 16–41 0–2 8h–33 0–5 12h–32
Efficacy c (%) 97.6 (92.7) d 100 (100) d 98.9 (98.5) d 96.7 (94.7) d
P-value < 0.001 < 0.001 < 0.001 < 0.001
5 Meanb tick counts (n) 0.7 (1.8) 21.1 (25.0) 0 (0) 26.4 (26.9) 0 (0) 28.8 (29.8) 0.1 (0.1) 22.3 (23.1)
Count range (n) 0–11 2i–40 0 19–37 0 18–43 1–0 13–33
Efficacy c (%) 96.6 (92.8) d 100 (100) d 100 (100) d 99.7 (99.6) d
P-value ≤ 0.001 ≤ 0.001 ≤ 0.001 ≤ 0.001
6 Meanb tick counts (n) 0.1 (0.1) 30.4 (30.8) 0.1 (0.1) 24.0 (24.5) 0.1 (0.1) 17.6 (18.7) 0.0 (0.0) 17.8 (18.3)
Count range (n) 0–1 21–38 0–1 18–31 0–1 12j–33 0 11j–25
Efficacy c (%) 99.8 (99.7) d 99.7 (99.6) d 99.6 (99.5) d 100 (100) d
P-value < 0.001 < 0.001 < 0.001 < 0.001
  1. aAssessment of ticks 48 h (± 4 h) after treatment or re-infestation following treatment; bGeometric mean (arithmetic mean); cCalculated based on geometric mean (arithmetic mean); dLog-counts of live ticks from the treatment group were significantly different (P ≤ 0.05) from log-counts of the respective untreated control group
  2. e eight from ten dogs adequately infested; f seven from eight dogs adequately infested (Study day (SD) 2), five from eight dogs adequately infested (SD 30); g four from eight dogs adequately infested (SD 2), six from eight dogs adequately infested (SD 58), six from eight dogs adequately infested (SD 86); h eight from ten dogs adequately infested (Study day (SD) 58 and SD 86): i nine from ten dogs adequately infested (Study day (SD) 2); j eight from ten dogs adequately infested (SD58), nine from ten dogs adequately infested (SD86)