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Table 1 Geometric (arithmetic) mean live flea counts and percent efficacy against the Wildcat strain of C. f. felis infesting cats treated with either an imidacloprid/flumethrin collar or a fipronil/(s)-methoprene topical spot-on

From: Evaluation and comparison of a flumethrin-imidacloprid collar and repeated monthly treatments of fipronil/(s)-methoprene to control flea, Ctenocephalides f. felis, infestations on cats for eight months

 

Non-treated controlsd,g

Imidacloprid/flumethrine,g

Fipronil/(s)-methoprenef,g

Study day

Mean No. of fleas

Mean No. of fleas

% controlh

Geomeans

Mean No. of fleas

% controlh

Geomeans

2

55.0a (55.8)

0 (0)

100b

0.1 (0.1)

99.9b

8

55.3a (57.9)

0 (0)

100b

0.6 (1.0)

98.8b

15

52.0a (53.5)

0.9 (1.4)

98.3b

0.4 (0.7)

99.1b

30

47.0a (48.7)

0 (0)

100b

0.2 (0.4)

99.5b

60

35.7a (36.6)

0 (0)

100b

1.0 (2.5)

97.2b

90

40.4a (42.4)

0 (0)

100b

12.8 (15.7)

68.2c

120

38.8a (39.6)

0.1 (0.1)

99.8b

1.9 (4.0)

95.0b

150

45.9a (47.3)

0 (0)

100b

7.1 (10.4)

84.5c

180

38.3a (40.2)

0 (0)

100b

1.5 (2.6)

96.1b

210

46.8a (47.3)

0.1 (0.1)

99.8b

12.5 (14.0)

73.3c

240

48.5a (50.9)

0.9 (1.4)

98.2b

3.3 (4.1)

93.2b

  1. d Each of 10 cats in the control group received no treatment
  2. e Each of 10 cats in the imidacloprid/flumethrin group were fitted with a Seresto® collar (Bayer Animal Health) on day 0. Note that two cats were removed from this group (one on study day 2 and one on study day 10)
  3. f Each of ten cats in the fipronil/(s)-methoprene group were treated Frontline® Plus for Cats and Kittens (Merial) on day 0 and then monthly through day 210
  4. g Each cat was infested with 100 adult C. f. felis on days 0, 7, 14, 29, 59, 89, 119, 149, 179, 209, and 239
  5. h % efficacy/Control = (GM flea count (control) – GM flea count (treatment) × 100)/GM flea count (control) \( \%\kern0.5em \mathrm{Control}=\frac{\mathrm{geometric}\;\mathrm{mean}\;\mathrm{count}\ \mathrm{control}\hbox{-} \mathrm{geometric}\ \mathrm{mean}\ \mathrm{count}\ \mathrm{treatment}}{\mathrm{geometric}\ \mathrm{mean}\ \mathrm{count}\ \mathrm{treatment}}\times 100 \)
  6. a,b,c Values across rows with unlike superscripts are significantly different (P < 0.0001)